氏 名 東 寛
所 属 小児科学講座
役職名 小児科教授
専門分野 感染・免疫/アレルギー/腫瘍免疫
出身大学(期) 旭川医科大学(1期)
国内・国外留学など
Department of Micorbilogy, Dartmouth Medical School
所属学会・
専門医
日本小児科学会、日本小児感染症学会、日本血液学会、日本造血細胞移植学会、日本輸血・細胞治療学会、日本血液代替物学会
専門詳細 先天性免疫不全症の病態と病因
各種疾患におけるサイトカインの産生動態
研究テーマ・
内容
1:抑制性マクロファージの人為的誘導の可能性について
2:炎症性サイトカイン産生の制御メカニズムの解明
3:人工赤血球の免疫機構に与える影響
英文業績
(1996〜2011)
  • Taguchi T, Okuno A, Fujita K, Sanae N, Azuma H, Yoshioka H. Etiologic factors in acute supprative thyroiditis. J Infect Dis. 146:447, 1982
  • Fujita K, Iseki K, Azuma H, Yoshioka H, Onozawa T. Subacute symmetrical osteomyelitis. Arch Pediat Adol Med. 139:750-751, 1985
  • Azuma H, Cho K, Fujita K, Yoshioka H Severe atopic manifestation after varicella in a yong infant Acta Paediatr Jpn 25:316-318, 1983
  • Azuma H, Green W.R. Clonal heterogeneity of Anti-AKR/Gross Leukemia Virus Cytotoxic T Lymphocytes : Evidence for Two Distinct Antigen Systems. J Immunol 7:2464-2473, 1987
  • Azuma H, Wegmann KW, Green WR. Correlations of in vivo growth of CTL susceptible and -resistant variant tumor cell lines in CTL-responder AKR.H-2b: Fv-1b and -non responder AKR.H-2b mice. Cellular Immunology 116:123-134, 1988
  • Ueda D, Taketazu M, Itoh S, Azuma H, Oshima H. A case of gastric duplication cyst with aberrant pancreas. Pediatr Radiol 21:379-380, 1991
  • Ueda D, Azuma H, Sakata Y, Sasaki K, Okuno K. Aminophylline suppository-induced acute proctitis. Am. J. Gastroenterol 87:889-890, 199
  • Ueda D, SakataY, SasakiK,AzumaH. An Increased ability to generate hydrog en peroxidase in certain Polymorphonucar leukocytes in neonate. Biol Neonate 62:63-66, 1992
  • Azuma H, Oomi H, Ueda D, Sasaki K, MakitaY, Fujita K, Yoshioka H., Okuno K, Tomizawa KSakiyama, Y Cytochrome b positive X-linked chronic granulomatous disease: a normal cell surface expression of cytochrome b. Eur J Pediatr 151:279-282, 1993
  • Azuma, H., Sakata, H., Saijyou, M., Okuno, An Effect of interleukin 2 on intractable herpes virus infection and chronic eczematoid dermatits in a patient with Wiskott-Aldrich syndrome. Eur J Pediatr 152:998-1000, 1993
  • Azuma H, Oomi H, Sasaki H, Kawabata I, Sakaino T, Koyano S, Suzutani T, Nunoi H, Okuno A. A New Mutation in exon 12 of the gp91-phox gene leading to Cytochrome b-positive X-linked chronic granulomatous disease. Blood 85: 3274-3277, 1995
  • Takahashi S, Miyamoto A, Oki J, Azuma H, Okuno A. Acute transvers myelitis caused by ECHO viurs type 18 infection. Eur J Pediatr 154:378-380,1995
  • Azuma H, Sakata Y, Sasaki K, Oka T, Hironaka T, Hirai K, Shosuke Imai, Osato T, Okuno K. Hodgkin disease occurring in a patient with extremely high serum antibody titers to Epstein-Barr Virus-Associated antigens without chronic illness, J Pediatr Hematology/Oncology 18: 387-391, 1996
  • Azuma H, Sasaki K, Miyamoto K, Tanaka K, Kato H, Uemoto,S, Okuno A. Atypical Epstein-Barr virus infection during and after intermittent FK506 therapy. Acta Paediatrica Japonica 39:222-225, 1997
  • Azuma H, Makita Y, Araki A, Miyamoto A, Tsuchida A, Takahashi S, Ooshima M, Okuno A. Elavated interleukin 6 without pleo-cytosis in cerebrospinalfluid in encephalitis patients Eur J Pediatr 156: 507-508, 1997
  • Azuma H, Tusda N, Sasaki K, Okuno A. Clinical significance of cytokines measurement for the detction of menigntitis JPediatr 131: 463-465, 1997
  • Nishi M, Miyake H, Takeda T, Hanai J et al. The relationship between homovanillic/ vanillylmandelic acid ratio and prognosis in neuroblastoma. Oncology reports. 5:361-633, 1998.
  • Sekine I, Dabashi H, Kogawa K Hirota T, Katano K, Azuma H, Fujimoto T. Hepatitis C virus infection and chronic liver disease after treatment of malignant disease in chileren: a multicenter study from the Chileren’s Cancer and Leukemia Group of Japan. Int J Clin Oncol 3:247-252, 1998.
  • Yokota S, Nakao M, Horiike S, Seriu T, Iwai T, Kaneko H, Azuma H, Fujimoto T et al. Muntational analusis of the N-ras gene in acute lymphoblastic leukaemia: a study of Japanese pediatric cases. Int J Hematol 67: 379-387, 1998.
  • Iwai T, YOkoata S, Nakao M, Nakazawa N, Taniwaki M, Kimura T, Sonoda Y, Kaneko H, Okuda T, Azuma H, Oka T. et al. Frequent aberration of FHIT gene expression in acute keukemia. Cancer Research 58:5182-5187, 1998.
  • Kawano Y, Takaue Y, Mimaya J,Horikoshi Y, Watanabe T, Abe T, Azuma H et al. Marginal benefit/disadvantage of granulocyte colony-stimulating factor therapy after autologous blood stem cell transplantation in children: Result of a prognostic randomized trial. Blood 92:4040-4046, 1988
  • Takahashi S, Oki J, MIyamoto A, Koyano S, Ito S, Azuma H, Okuno A. Encepahlopathy associated with haemo-phagocytic lymphohistiocytosis  following rotavirus infection Eur J PEdiatr 158:133-137, 1999
  • Oshima M, Azuma H, Okuno A. High prevalence of Epstein-Barr virus  type A strain with the 30b.p. delation of the latent membrane protein-1 gene in a Japanese population. Pediatr Int 41:490-495, 1999
  • Azuma H, Moriyama T, Ikeda, Oshima M, Okuno A, Sekiguchi S Analysis of solluble interleukin 6 receptor in cerebrospinal fluid in inflammatory andnon-inflammatory conditions Cytokine 12: 160-164, 2000
  • Azuma H, Oshima M, Ito K, Okuno A, Kawabata I, Banba K, Murahashi H, Sekine T, Kato Y, Ikebuchi K, Ikeda H.Impaired IL2 production in T cells from a patient with Wiskott-Aldrich syndrome : basis of clinical effect of interleukin-2 replacement therapy. Eur J Pediatr. 2000 Aug;159:633-634.
  • Azuma H, Ikebuchi K, Yamaguchi M, Murahashi H, Mogi Y, Sato N, Fujihara M, Hirayama F, Ikeda H. Comparison of sensitivity to ultraviolet B irradiation between human lymphocytes and hematopoietic stem cells. Blood 96:2632-2634, 2000.
  • Oshima M, Azuma H, Suzutani T, Ikeda H, Okuno A. Direct and mononuclear cell mediated effect on interleukin 6 production by glioma cells in infection withherpes simplex virus type 1. J Med virology 63: 252-258, 2001
  • Azuma H, Yamada Y, Fujiwara N, Yamaguchi M, Murahashi H, Fujihara M, Sato N, Fukazawa K, Ikebuchi K, Ikeda H. Functional evaluation of ex vivo expanded cord blood lymphocytes---Possible use for adoptive cellular immuneotherapy----Exp. Hematol 30:346-351, 2002
  • Yamaguchi M, Hirayama F, Wakamoto S, Fujihara M, Murahashi H, Sato N, Ikebuchi K, Sawada K, Koike T, Kuwabara M, Azuma H, Ikeda H. Bone marrow stromal cells prepared using AB serum and bFGF for hematopoietic stem cells expansion. Transfusion 42: 921-927, 2002
  • Yamaguchi M, Hirayama F, Murahashi H, Azuma H, Sato N, Miyazaki H, Fukazawa K, Sawada K, Koike T, Kuwabara M Ikeda K, Ikebuchi K. Ex vivo expansion of huma UC blood primitive hematopoietic progentors and transplantable stem cells using human primary BM cells and human AB serum. Cytotherapy 4:109-118, 2002
  • Odawara F, Abe H, Kohno T, Nagai-Fujii Y, Arai K, Imamura S, Misaki H, Azuma H et al. A higyly sensitive chemiluminescence reverse transcriptase assay for human immunodeficiency virus. J Virol Method 106:115-124, 2002.
  • Kurosaki Y, Abe H, Morioka H, Hirayama J, Ikebuchi K, Kamo N, Nikaodo O, Azuma H, Ikeda H. Pyrimidine dimmer formation and oxidative damage in M13 bacteriophage inactivation by ultraviolet C irradiation. Photochem Photbil 78:349-354, 2003.
  • Ito T, Fujihara M, Oda A, Wakamoto S, Yamaguchi M, Komatsu N, Miyazaki H, Azuma H, Ikeda H, Ikebuchi K. Thromobopoietin upregulation nucleolin mRNA and protein in thromobpoietin-dependent megakaryocytic cell line, UT-7/TPO. Mol Cell Biochem 247:75-82, 2003.
  • Hirayama F, Yamaguchi M, Yano M, Yasui K, Horie Y, Matsumoto K, Nagao N, Ikebuchi K, Azuma H, Ikeda H, Yani Y. Spontaneous and rapid reexpression of functional CXCR4 by human steady-state peripheral blood CD34+ cells. Int J Hematolgy 78:48-55, 2003.
  • Kawano Y, Kobune M, Yamaguchi M, Nakamura K, Azuma H, Ikeda H, Niitsu Y, Hamada H. Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subumit(hTERT)-transfected human stromal cells. Blood 101:532-540, 2003
  • Wakamoto S, Fuiihara M, Kuzuma K, Sato S, Kato T, Kenji Ikebucchi K, Azuma H, Hisami I. Biologic activity of RANTES I apheresis PLT concentrates and its involvement in nonhemolytic transfusion reactions. Transfusion 43: 1038-1046, 2003.
  • Murahashi H, Azuma H, Zamzami N, Furuya K, Ikebuchi K,Ymaguchi M, Yamada Y, Sato N, Fujihara M, Kroemer G, Ikeda H. Possible contribution of apoptosis-inducing factor(AIF) and reactive oxygen species(ROS) to UVB-induced caspase-independent cell death in the T cell line Jurkat. J Leukocyte Biol 73: 399-406, 2003
  • Yamada Y, Azuma H Urushibara N, Yamaguchi M, Fujihara M, KobataT, Ikeda H. Cytotxic defference of T cells expanded with anti-CD3 monoclonal antibody in the presence and absence of anti-CD28 monoclonal antibody. Stem cells and development 13: 315-322, 2004.
  • Wakamoto S,Fujihara M, Abe H, Yamaguchi M,Azuma H,Ikeda H,Takeoka S,Tsuchida E Effects of hemoglobin vesicles on resting and agonist-stimulated human platelets in vitro Artif. Cells Blood Substit. Immobil. Biotechnol. 33(2) : 101-111,2005
  • Morishita K, Wakamoto S, Miyazaki T, Sato S, Fujihara M, Kaneko S, Yasuda H, Yamamoto S, Azuma H, Kato T, Ikeda H. Life-threatening adverse reaction followed by thrombocytopenia after passive transfusion of fresh frozen plasma containing anti-CD36 (Nak) isoantibody. Transfusion. 45:803-806, 2005
  • Wakamoto S, Fujihara M, Urushibara N, Morishita K, Kaneko S, Yasuda H, Takayama H, Yamamoto S, Azuma H, Ikeda H. Heterogeneity of platelet responsiveness to anti-CD36 in plasma associated with adverse transfusion reactions. Vox Sang 88: 41-51, 2005.
  • Hirayama J, Abe H, Azuma H,Ikeda H Leakage of potassium from red blood cells following gamma ray irradiation in the presence of dipyridamole, trolox, human plasma or mannitol. Biol. Pharm. Bull. 28 : 1318-1320,2005.
  • Fujihara M, Akino M, Sato M, Wakamoto S, Azuma H, Ikeda H. Prestorage leucofiltration prevents the accumulation of matrix metalloproteinase-9 in red cell concentrates stored in mannitol-adenine-phosphate medium. Vox Sang. 89(2) : 114-115, 2005
  • Owada T, Matsubayashi K, Sakata H, Ihara H,Sato S, Ikebuchi K, Kato K, Azuma H, Ikeda H. Interaction between desialylated hepatitis B virus and asialoglycoprotein receptor on hepatocytes may be indispensable for viral binding and entryJ. Viral. Hepat. 13(1) : 11-18, 2006.
  • Abe H, Fujihara M, Azuma H,Ikeda H,Ikebuchi K,Takeoka S,Tsuchida E,Harashima H Interaction of hemoglobin vesicles, a cellular-type artificial oxygen carrier, with human plasma: effects on coagulation, kallikrein-kinin, and complement systems. Artif. Cells Blood Substit. Immobil. Biotechnol. 34:1-10,2006
  • Okajima S,Cho K,Chiba H,Azuma H,Mochizuki T, Yamaguchi M,Sato S, Ikeda H,Yamada H, Minakami H,Ariga T,Kobayashi T. Two sibling cases of hydrops fetalis due to alloimmune anti-CD36 (Naka) antibody. Thromb. Haemost. 95(2) : 267-271,2006
  • Sakakawa H, Azuma H, Fujihara M, Ikeda H. Clinical-scale expansion of human cytomegalovirus-specific cytotoxic T lymphocytes from peripheral blood mononuclear cells requiring single-peptide stimulation and feeder cells but not additional antigen-presenting cells. Transfusion 46: 516-522. 2006
  • Sakagawa H, Miyazaki T, Fujihara M, Sato S, Yamaguchi M, Fukai K, Morishita M, Kato K, Azuma H, Ikeda H. Generation of inflammatory cytokines and chemokines from periperal blood mononuclear cells by HLA class II antibody-containing plasma unit that was associated with sever nonhemolytic transfusion reactions. Transfusion 47: 154-160, 2007
  • Abe H, Azuma H, Yamaguchi M, Fujihara M, Ikeda H, Sakai S, Takeoka S, Tsuchida E. Effect of hemoglobin vesicles, a liposomal artificial oxygen carrier, on hemmatological responses, complement and anaphylactic reactions in Rats. Artif Cells Blood Substit and Biotechnol 35: 157-172, 2007
  • Yamaguchi M, Azuma H, Fujihara M, Hamada H, Ikeda H. Generation of a considerable number of functional mast cells with ahigh basal level of FceRI expression from cord blood CD34+ cells by co-culturing then with bone marrow stromal cell line under serum-free conditions. Sca J Immunol 65: 581-588, 2007
  • Hirayama J, Azuma H, Fujihara M, Homma C, Yamamoto S, Ikeda H. Storage of platelets in a novel additive solution (M-sol) consisting solely of commercially available medical solutions. Transfusion 47: 960-965, 2007
  • Omura M, Furuya K, Kudo S, Sugiura W, Azuma H. Detecting immunoglobulin M antibodies against microsporidian Encephalitozoon cuniculi polar tubes in sera from healthy and human immunodeficiency virus-infected persons in Japan. Clin. Vaccine Immunol. 14: 168-172, 2007
  • Komatsu T, Huang T, Wakamoto S, Abe H, Fujihara M, Azuma H, Ikeda H, Yamamoto H, Horinouchi H, Kobayashi K, Tsuchida E. Influence of 02-carring plasma hemoprotein ”albumin-heme” on cocmplement system and platelet activation in vitro and physisological response to exchange trasfusion. J Biomed Mater Res 81A: 821-826, 2007
  • Nagamura-Inoue T, Kai S, Azuma H. Takanashi M, Isoyama K, Kato K et al. Unrelated cord blood transplantation in CML:Japan Cord Blood Bank Network anaysis. Bone Marrow Transpl 42:241-251, 2008
  • Yoshimi A, Kojima S, Taniguchi S, Hara J, Matsui T, Takahashi Y, Azuma H, Kato K et alUnrelated cord blood transplantation for sever aplastic anemia. Biol Blood Marrow Transplant 14: 1057-1063, 2008.
  • Furuya K, Omura M, Kudo S, Sugiura W, Azuma H. Recognition of profiles of microspridian encephalitozoon cuniculi polar tube prtein 1 with human immunoglobulin M antibody. Parasite Immunol 30:13-21, 2008
  • Wakamoto S, Fujihara M, Sakagawa H, Takahashi D, Niwa K, MOrishita M, Sato S, Kato T, Azuma H, Ikeda H. Endothelial permeability is increased by the supernatant of peripheral blood mononuclear cells stimulated with HLA Class II antibody. Transfusion 48:2060-2068, 2008
  • Yamaguchi M, Fujihara M, Wakamoto S, Sakai H, Takeoka S, Eishun T, Azuma H, Hisami Ikeda. Infulence of haemoglobin vesicles, cellular-type artificial oxygen carriers, on human umbilical cord blood hematopoietic progenitor cells in vitro. J Biomate Res 88:34-42, 2009
  • Azuma H, Hirayama J, Akino M, Miura R, Kiyama Y, Imai K, Kasai M, Koizumi K, Kakinoki Y, Makiguchi Y, Kubo K, Atusta Y, Fujihara M, Homma C, Yamamoto S, Kato T, Ikeda H. Redcution in adverse reactions to platelets by the removal of plasma supernatant and resuspension in a new additive solution(M-sol). Transfusion;49: 214-218, 2009
  • Matsuya N, Hirayama F, Wakamoto S, Yasui K, Furuta RA, Kimura T, Taniue A, Fukumori Y, Fujihara M, Azuma H, Tani Y, Shibata H. Application of the basophil activation test in the analysis of allergic transfusion reactions. Transfus Med. 9(5):274-277, 2009
  • Yamaguchi M, Fujihara M, Wakamoto S, Sakai H, Takeoka S, Tsuchida E, Hamada H, Azuma H, Ikeda H. Biocompatibility study of haemoglobin vesicles, cellular-type artificial oxygen carriers, with human umbilical cord hematopoietic stem /progenitor cells using an in vitro expansion system. ASAIO 55(3):200-2005, 2009
  • Atsuta Y, Suzuki R, Nagamura-Inoue T, Taniguchi S, Takahashi S, Kai S, Sakamaki H, Kouzai Y, Kasai M, Fukuda T, Azuma H, et al. Disease-specific analysis of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia. Blood 113:1631-1638, 2009
  • Hirayama J, Kojima S, Akino M, Fujihara M, Kanai H, Homma C, Azuma H, Yamamoto S, Kato T, Ikeda H. The effect of radiation on platelet in M-sol additive solution with 30% residual plasma. Tranfusion 49: 813-815, 2009
  • Azuma H, Ikeda H. Washed/replaced(W/R)-platelets. Vox Sanguinis, ISBT Science Series, 4:342-346, 2009
  • Fujihara M, Wakamoto S, Azuma H, Ikeda H. Involvement of human leukocyte antigen class II antibody in pathogenesis of transfusion-related acute lung injury(TRALI):vascular permeability Enhancement. Vascular Disease Prevention. 6:170-177, 2009
  • Azuma H, Yamaguchi M, Takahashi D, Fujihara M, Sato S, Kato T, Ikeda H. ElavatedCa2+ influx-inducing activity toward mast cells in pretransfusion sera from patients who developed transfusion-related adverse reactions. Transfusion 49:1754-1761, 2009
  • Takahashi D, Fujihara M, Azuma H, Miyazaki T, Uchimura D, Wakamoto S, Sato S, Kato T, Ikea H. Stimulation of human neutrophils with sera containing HLA class I alloantibody causes preferential degranulation of azurophilic granules and secretory vesicles. Vox Sang 98:560-566. 2010
  • Takanashi M, Atsuta Y, FUjikawa K, Kodo H, Kai S, Sato H, Kohsaki M, Azuma. H, Tanaka H, Ogawa A, Nakajima K, Kato S. The impact of anti-HLA antibodies on unrelated cord blood transplantations. Blood 116;2839-2846, 2010.
  • Hirayama J, Azuma H, Fujihara M, Akino M, Homma C, Kato T, Ikeda H. Comparison between in vitro qualities of platelets washed with commericaly available additive solutions and those with M-sol. Vox Sang 99:131-135, 2010
  • Fujihara M, Azuma H, Ikeda H, Yamaguchi M, Hamada H. Bone Marrow Stromal Cell Line Promotes the Proliferation of Mast Cell Progenitors Derived from Cord Blood CD34+ Cells under Serum-free Conditions with a Combination of Both Cell-cell Interaction and Soluble Factors Artif. Cells Blood Substit Biotechnol 39:51-58, 2011
  • Azuma H, Hirayama J, Akino M, Ikeda H. Platelet additive solution-Electrolytes. Transfusion and Apheresis Science 44: 277-281, 2011
  • Wakamoto S, Fujihara M, Takahashi D, NIwa K, Sato S, Kato T, Azuma H, Ikeda H. Enhancement of endothelial permeability by coculture with peripheral blood mononuclear cells in the presence of HLA class II antibody that was associated with transfusion-related acute lung injury. Transfusion 51:993-1001, 2011
  • Takahashi D, Azuma H, Sakai H, Sou K, Wakita D, Abe H, Fujihara M, Horinouchi H, Nishimura T, Kobayashi K, Ikeda H. Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture condtions. J Pharmacol Exp Ther 337:42-49, 2011
  • Takahashi D, Fujihara M, Azuma H, Wakamoto S, Sato S, Kato T, Ikeda H. Adhesive interaction between peripheral blood mononuclear cells and activated platelets in the presence of anti-human leukocyte antigen class I alloantibody causes production of IL-1b and IL-8. Vox Sang 2011 [Epub ahead of print]
  • Hirayama J, Azuma H, Fujihara M, Akino M, Homma C, Kato T, Ikeda H. Comparison between bacterial growth in platelets (PLTs) washed with M-sol and that in PLT-rich plasma. Transfusion 51:1592-1594, 2011
競争的研究費獲得
A) 文部科学研究費補助金
S63-64: 科学研究費症例(A)(01770628)
  B細胞分化因子(BSF2/IL6)と低ガンマグロブリン血症との関連性に関する研究

H6 : 文部科学研究費一般(C) (06670758)

  髄液中Interleukin 6およびその可溶性リガンドの動態に関する研究

H16-18 : 科学研究費(基盤研究 B 一般)

  プロテオソーム解析に基づくミクロスポリジア感染の疫学的研究
 研究代表者:古屋宏二(国立感染症研究所 寄生動物部)
 研究分担者:東 寛
 平成16年度:600,000円, 平成17年度:600,000円, 平成18年度:600,000円
   
B) 厚生労働省科学研究費補助金
1) 医薬品・医療機器等レギュラトリーサイエンス総合研究事業
  a) 院内血液製剤の適正な製造体制・順守基準に関する研究 (H20-医薬-一般-006)
 研究代表者:大戸 斉(福島医科大学輸血移植免疫学講座)
 研究分担者:東 寛
 平成20年度:400,000円, 平成21年度:470,000円
  b) 輸血副作用把握体制の確立
-特に免疫学的副作用の実態把握とその対応- (H20-医薬-一般-009)
 研究代表者:高本 滋(愛知医科大学医学部輸血部)
 研究協力者:東 寛
 平成20年度:250,000円, 平成21年度:200,000円, 平成22年度:250,000円
2) 創薬基盤推進研究事業
  a) 人工赤血球のICU使用を目的とした最適化およびME技術の改良に関する研究 (H20-政策創薬- 一般-005)
 研究代表者:武田 純三(慶応義塾大学医学部)
 研究分担者:東 寛
 平成20年度:2,500,000円
3) ヒトゲノム再生医療等研究事業
   研究代表者:齊藤英彦(国立病院機構 名古屋医療センター)
 連携研究者:東 寛 平成17年度:500,000円, 平成18年度:500,000円
   
C) 秋山記念財団研究助成金
  H2 :チトクロームb558を有する伴性劣性肉芽腫症の病院の解析
   
D)その他
1)人工赤血球の臨床応用を目指した指摘投与法の策定とGMP製造技術の確立 
 (H21-政策創薬-一般-006)
   研究代表者:堀之内宏久(慶応義塾大学医学部)
 分担研究者:池田久實(現北海道赤十字血液センター長)
 平成21年度:4,000,000円
 平成22年度:4,000,000円
一 言 あきらめずにこつこつと