英文業績　─ 著書 ─

Hiroshige T, Abe K, Kaneko M, Wada S and Fujieda K : Dynamics of the regulation of CRF content in the rat hypothalamus under resting and stressful conditions., Psychoneuroendocrinology, Hatotani R.ed, S.Karger,A.G,Basel, pp102-112, 1974 Hiroshige T, Honma K, Fujieda K, Kaneko M and Honma S:Rhythms in the CRF-ACTH-Corticosteroid Axis. Proc. of the Vth Int. Congr. of Endocrinology, V.H.T. James ed, Excerpta Medica, Amsterdam, Vol.1, pp77-83, 1977 Hiroshige T and Fujieda K : Ontogenesis of stress-induced incremental response of hypothalamic CRF activity in the rat, Hormones and Development, Macho L and Strbak S eds, VEDA, Publishing House of the Slovak Academy of Sciences, Bratislave, pp193-206, 1979 Winter J.S.D, Fujieda K, Faiman C, Reyes F.I.and Thliveris J: Control of steroidogenesis by human fetal adrenal cells in tissue culture, Adrenal Androgens, Genazzani A.R, Thijssen J.H.H and Sitteri P.K eds, Raven Press,New York, pp55-62, 1980 Matsuura N, Hibi I, Tanae A, Maruyama H, Tsuchiya H, Ishiki G, Mikami Y, Fukushima N and Fujieda K : Epidemiology of IDDM in Japan,1973-1980(0-15 years at onset), Childhood and Juvenile Diabetes Mellitus, Mimura G ed, Current Clinical Practice Series 27, Excepta Medica, pp27-32, 1985 Matsuura N, Mikami Y, Fujita H, Abe K, Fukushima N, Fujieda K, Nohara Y and Kato T : Summer camps for diabetic children in the Hokkaido,Children and Juvenile Diabetes Mellitus, Mimura G ed, Current Clinical Practice Series 27, Excepta Medica, pp201-204, 1985 Matsuura N, Fujieda K, Nakajima H, Konishi J, Irie M, Fukushi M and Takasugi N:Transient hypothyroidism in the newborn infant-A nationwide study,Advances in Neonatal Screening, Therrell B.L ed, Elsevier Science Publishers B.V, pp49-52, 1987 Ichihara N, Kizaki T, Sakurada N, Kumagai M, Matsuura N, Fujieda K, Oyanagi K, Naruse H and Suzuki E : Application of a new enzyme immunoassay using GOD-conjugate to mass-screening for congenital adrenal hyperplasia. Advances in Neonatal Screening, Therrell B.L ed, Elsevier Science Publishers B.V, pp147-148, 1987 Fukushi M, Arai O, Mizushima Y, Takasugi N, Fujieda K and Matsuura N: A method for quantitative analysis of adrenal steroids with high performance liquid chromatography for diagnosis of congenital adrenal hyperplasia, Advances in Neonatal Screening , Therrell B.L ed, Elsevier Science Publishers B.V, pp143-144, 1987 Fukushi M, Arai O, Mizushima Y, Takasugi N, Fujieda K and Matsuura N:Enzyme-l inked immunosorbent assays for 17-hydroxyprogesterone and cortisol in dried blood samples on filter paper and it's application to neonatal screening for congenital adrenal hyperplasia. Advances in Neonatal Screening, Therrell B.L ed, Elsevier Science Publishers B.V, pp303-304, 1987 Suwa S, Shimozawa K, Kitagawa T, Fujieda K, Matsuura N, Takasugi N, Fukushi M, Igarashi Y and Takahashi T : Collaborate study on regional neonatal screeing for congenital adrenal hyperplasia in Japan, Advances in Neonatal Screening, Therrell B.L ed, Elsevier Science Publishers B.V, pp279-280, 1987 Fujieda K, Matsuura N, Takasugi N, Fukushi M, Arai O and Mizushima Y : Five years experience of newborn screening program for congenital adrenal hyperplasia in Sapporo. Advances in Neonatal Screening, Therrell B.L ed, Elsevier Science Publishers B.V, pp281-286, 1987 Igarashi Y, Ogawa H, Hikita Y, Toya K, Ishiguro M, Yamashita Y, Suwa S, Tanae A, Shimozawa K, Fujieda K and Fukushi M:21-Hydroxylase deficiency, Neonatal Mass-screening. Controversies in Disorders of Adrenal Hormones, Takeda R and Miyamori I eds, Elsevier Science Publishers B.V, pp157-168, 1988 Pang S, Dobbins R.H, Kling S, Thuline H, Hofman L, Lyon C.T, Webster D.R, Dorche C, Dhondt J.L, Wallace M.A, Fujieda K and Suwa S : Worldwide newborn screening update for classical congenital adrenal hyperplasia, Current Trends in Infant Screening, Schmidt B.J ed, Elsevier Science Publishers B.V, pp307-312, 1989 Matsuura N, Konishi J, Harada S, Yuri K, Fujieda K, Kasagi K, Iida Y, Fujimoto S, Hagisawa M, Fukushi M and Takasugi N : TSH-receptor antibodies in mothers with autoimmune thyroid disease and outcome in their offspring. Progress in Thyroidology, Lee M, Koh C-S, Eastman C.J and Nagataki S eds, Korea Med Publishing Company, pp123-126, 1989 Matsuura N, Konishi J, Fujieda K, Yuri K, Harada S, Kasagi K, Iida J, Endo M and Yamada Y : Transient hypothyroidism in infants due to maternal TSH-receptor blocking antibodies -character of their IgG and long-term prognosis of their infants. Research in Congenital Hypothyroidism, Delange F, Fisher D.A. and Glinoer D eds, Plenum Publishing Corporation, pp111-122, 1989 Matsuura N, Harada S, Yuri K, Fujieda K, Okuno A and Hosoda A : The role of TSH-receptor blocking antibodies in congenital hypothyroidism, Thyroid gland, Environment and Autoimmunity, Drexhage H.A, de Vijlder J.J.M, Wiersinga W.M eds, Elsevier Science Publishers B.V, pp307-313, 1990 Shinohara N, Fujieda K, Matsuura N, Okuno A, Hosoda A, Kato M : Maintaining normal growth despite the presense of GH deficiency and low IGF-I value after operation of craniopharyngioma : Report of a case. Proceedings the 4th Meeting of the Research Society for the Growth Disturbance in Children, Suwa S ed, JEFF Corporation Co, Ltd, pp 77-83, 1991. Fujieda K, Hosoda A, Matsuura N, Yuri K, Harada S, Okuno A, Fukushi M and Matsumoto S: Pulsatile secretion of gonadotropin in pre- and pubertal children. Progress in Chronobiology, Hiroshige T, Fujimoto S and Honma K eds, Hokkaido University Press, pp 130-139, 1992 Matsuura N, Fujieda K, Harada S, Yuri K, Fujimoto S, Hagisawa M, Fukushi K and Takasugi N : TSH receptor antibodies in mothers with autoimmune thyroid disease and outcome in their offspring. Progress in Chronobiology, Hiroshige T, Fujimoto S and Honma K eds, Hokkaido University Press, pp108-115, 1992 Pang S, Clark A, Winter J, Dean H, Dhondt J, Farriaux J, Dorche C.H, Harras A, Gruters A, Helge H, Cacciari C, Kizaki T, Ichihara N, Arai A, Harada S, Matsuura N, Suwa S, Kusuda S, Fujita K, Fukushi M, Mizushima Y, Kikuchi Y, Fujieda K, Webster D,Osorio R, Vilarinho L, Wallace A, Equileor I, Marzana I , Dulin E, Fernandez A, Hagenfeld L, Guthenberg C, Dobeln U, Larsson A, Torresani A, Papadea C, Rumph F, Craft W, Kling S, Tsalikian E, Cook J, Mitchell M, Hofman L, Skeel M, Naylor E, Therrell B, Brown L, Prentice L, Glass M, Neier S:Congenital adrenal hyperplasia screening in a greater worldwide newborn population : Genetic frequency and the effectiveness of screening. Neonatal Screening in the Nineties, Wilckedn B and Webster D eds, Kelvin Press Manly Vale, NSW Australia, pp208-209, 1992 Igarashi Y, Ogawa E, Fujieda K, Tanaka T : Treatment of Turner syndrome with transdermal estradiol (Estraderm R). Basic and Clinical Approach to Turner Syndrome, Hibi I and Takano K eds, Elsevier Science Publishers, pp197-201, 1993 Fujieda K and Tajima T:Molecular genetics of congenital adrenal hyperplasia, New Trends in Neonatal Screening, Takasugi N and Naruse H eds, Hokkaido University Press, pp111-117, 1994 Fujieda K and Tajima T : Genetics of 21-hydroxylase deficiency. Sexual Differentiation and Maturation, Hibi I and Tanaka T eds, Frontiers in Endocrinology, Ares Serono Symposia, pp53-64, 1996 Fujieda K, Tajima T, Nakae J:Assessment of diagnostic and therapeutic criteria for congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency in newborn, Poceedings of the 20th Anniversary Nationawide Neonatal Screening in Japan, J Jap Soc Mass-screening vol 8, supple 1, Sakamoto S, Naruse H, and Matsuura N eds, pp75-80, 1998 Fujieda K:Endocrionological manifestations, Intracranial germ cell tumors, Sawamura Y, Shirato H, and de Tribolet N eds, Springer-Verlag, Wien, New York, pp128-136, 1998 Fujieda K, Tajima T, Nakae J:Molecular genetics of congenital adrenal disorders, Proceedings on The Ninth Fukuoka International Symposium on Perinatal Medicine, pp66-75, 1998 Fujieda K, Nakae J, Abe S, Tajima T: DAX-1 mutations in adrenal hypoplasia congenital. Molecular Steroidogenesis, Okamoto M, Ishimura Y, and Nawata H eds, Universal Academy Press, pp341-344, 2000 Mukai T, Shikayama K, Oka S, Fujieda K, Morohashi K: Expression of Dax-1 in the Adrenal Gland. Molecular Steroidogenesis, Okamoto M, Ishimura Y, and Nawata H eds, Universal Academy Press, pp223-224, 2000 Tanaka T, Takano K, Ogawa M, Tachibana K, Fujieda K, Hizuka N: Final height in Turner syndrome after grouth hormone treatment; Japanese study, Optimizing Health Care for Turner Patients in the 21st Century. Saenger P and Pasquino AM eds, Elsevier Science BV, pp223-228, 2000 Ranke MB, Keizer-Scharma de Muinck SMPF, Fujieda K: Management of girl with Turner syndrome. SCIENS Worldwide Medical Education Network, pp1-24, 2003 Fujieda K, Nakae J, Mukai T: 3β-hydroxysteroid dehydrogenase deficiency, Encyclopedia of Endocrine Disease. Martini L eds, Academic Press Vol 2, pp498-503, 2004 Fujieda K, Tanaka T:Diagnosis of children with short stature: Insights from KIGS. Ranke MB, Price DA, Reiter EO, eds. Growth hormone therapy in pediatrics, Karger, pp16-22, 2007

英文業績　─ 原著 ─

Matsuda I, Takekoshi Y, Shida N, Fujieda K, Nagai B, Arashima S, Anakura M and Oka Y: Renal tubular acidosis and skeletal demineralization in patients on long-term anticonvulsant therapy, J.Pediatr. 87:202-205, 1975 Hiroshige T, Fujieda K, Kaneko M and Honma K:Assays and dynamics of corticotropin- releasing factor activity in rat hypothalamus, Ann. N.Y.Acad.Sci. 297:436-454, 1977 Fujieda K and Hiroshige T:Changes in rat hypothalamic content of corticotropin releasing factor(CRF) activity, plasma ACTH and corticosterone under stress and the effect of cycloheximide, Acta Endocrinol(Kbh). 89:10-19, 1978 Blankstein J, Fujieda K, Reyes FI, Faiman C and Winter JSD:Cortisol, 11-desoxycortisol and 21-desoxycortisol in amniotic fluid during normal pregnancy, Am J Obstet Gynec 137:781-784, 1980 Blankstein J, Fujieda K, Reyes FI, Faiman C and Winter JSD: Aldosterone and corticosterone in amniotic fluid during various stages of pregnancy, Steroids. 36:161-165, 1980 Fujieda K, Reyes FI, Blankstein J and Faiman C: Pituitary-adrenal function in woman treated with low doses of prednisone, Am.J.Obstet.Gyn. 137:962-965, 1980 Fujieda K, Faiman C, Reyes FI and Winter JSD:The control of steroidogenesis by human fetal adrenal cells in tissue culture. I.Responses to ACTH, J Clin Endocrinol Metab. 53:34-38, 1981 Fujieda K, Faiman C, Reyes FI, Thliveris J and Winter JSD: The control of steroidogenesis by human fetal adrenal cells in tissue culture. II.Comparisons of morphology and steroid production in cells of the fetal and definitive zones, J Clin Endocrinol Metab. 53:401-405, 1981 Fujieda K, Faiman C, Reyes FI and Winter JSD:The control of steroidogenensis by human fetal adrenal cells in tissue culture. III. The effects of various peptide hormones, J Clin Endocrinol Metab. 53:690-693, 1981 Fujieda K, Faiman C, Reyes FI and Winter JSD:The control of steroidogenesis by human fetal adrenal cells in tissue culture. IV. Effects of exposure to placental steroids, J Clin Endocrinol Metab. 54:89-94,1982 Fujieda K, Goff AK, Pugeat M and Strott CA:Regulation of the pituitary-adrenal axis and corticosteroid-binding globulin-cortisol interaction in the guinea pig, Endocrinology. 111:1944-1950, 1982 Abe K, Matsuura N, Fujita H, Fujieda K, Kato T, Nohara Y, Mikami Y and Fukushima N: Prolactin response to arginine in children with hyperthyroidisim and primary hypothroidism, Eur J Pediatr. 139:118-120, 1983 Abe K, Matsuura N, Fukushima N, Nohara Y, Fujita H, Fujieda K and Kato T : Plasma prolactin response to thyrotropin releasing hormone in children with newly diagnosed insulin dependent diabetes, Tohoku.J.Exp.Med. 140:29-34, 1983 Matsuura N, Fukushima N, Fujita H, Abe K, Yamada Y, Kashiwao N, Fujieda K, Kato T, Mikami Y, Nohara Y, Fukuda K, Okuno A, Taguchi T and Oyanagi K: Epidemiologic survey of juvenile-onset insulin dependent diabetes (IDDM) in Hokkaido, Japan 1973-1981. Tohoku.J.Exp.Med.(Suppl) 141:181-189, 1983 Abe K, Matsuura N, Nohara Y, Fujita H, Fujieda K, Kato T and Mikami Y: Prolactin response to thyrotropin-releasing hormone in children with gynecomastia, premature thelarche and idiopathic precocious puberty, Tohoku.J.Exp.Med. 142:283-288, 1984 Nonomura K, Fujieda K, Sakakibara N, Terasawa K, Matsuno T, Matsuura N and Koyanagi T: Pituitary and gonadal function in prepubertal boys with hypospadias. J.Urol. 132: 595-598, 1984 Kato K, Hamada N, Mizukoshi N, Yamamoto K-I, Kimura T, Ishihara C, Fujioka Y, Kato T, Fujieda K and Matsuura N : Depression of delayed-type hypersensitivity in mice with hypothalamic lesion induced by monosodium glutamate : Involvement of neuroendocrine system in immunomodulation, Immunology58:389-395,1986 Fujieda K and Matsuura N : Growth and maturation in the male genitalia from birth to adolescence. I.Changes of testicular volume, Acta Pediatr Jpn 29:214-219, 1987 Fujieda K and Matsuura N : Growth and maturation in the male genitalia from birth to adolescence. II. Changes of penile size, Acta Pediatr Jpn 29:220-223,1987 Matsuura N, Fujieda K, Mikami Y, Fujita H, , Harada S, Wakisaka A, Shinjyo T and Hirata Y : Classification of type 1 and type 2 diabetes mellitus from studies of ICA, HLA andinsulin secretory capacity, Acta Pediatr Jpn 29:340-344,1987 Fujieda K and Matsuura N : Evaluation of daytime GH secretory dynamics for the diagnosis of GH deficiency, Acta Paediatr. Scand.343(Suppl):180-181,1988 Matsuura N, Fujieda K, Iida Y, Fujimoto S, Konishi J, Kasagi K, Hagisawa H, Fukushi M and Takasugi N : TSH receptor antibodies in mothers with Graves' disease and outcome of their offspring, Lancet.14-17,1988 Kato K, Chen Y, Nakane A, Minagawa T, Fujieda K, Kimura T and Yamamoto K : Suppression of delayed-type hypersensitivity in mice immunomodulation, J. Leukocyte Biol. 43:530-538,1988 Pang S, Wallace MM, Hofman L, Dorche C, Lyon ICT, Fujieda K and Suwa S : Worldwide experience new born screening for classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency, Pediatrics.81:866-874,1988 Matsumoto T, Kondoh T, Yoshimoto M, Fujieda K, Matsuura N, Matsuda I, Miike T, Yano K, Okuno A, Aoki Y, Murano I, Toyota S, Ohnishi Y and Niikawa N : Complex glycerol kinase deficiency : Molecular-genetic cytogenetic and clinical studies of five Japanese patients, Am.J.Med.Genet.31:603-616,1988 Fujieda K, Matsuura N, Mikami Y, , Harada S, Yuri K, Okuno A, Hosoda A and Aida T : Endocrine function and growth in children with CNS tumors - With special emphasis on germinom, Acta Pediatr Jpn 30(Suppl):61-67,1988 Demura R, Ishiwatari N, Nomura T, Demura H, Shizume K, Okuno A, Sanayama K and Fujieda K : Mesurements of plasma free and total growth hormone (GH) concentrations in patients with growth hormone antibodies developed in response to therapy, Acta Endocrin.(Kbh) 120:161-169,1989 Matsuura N, Fujieda K, Mikami Y, Harada S, Okuno A, Yuri K and Hosoda A : Epidemiological aspects of late complications of juvenile onset of diabetes in Hokkaido, Japan, Pediatr.Adolesc.Endocrinol.18:223-228,1989 Matsuura N, Mikami Y and Fujieda K : Advances in insulin therapy for insulin-dependent diabetic children, Indian J.Pediatr. 56(Suppl):51-56,1989 Matsuura N, Konishi J, Harada S,Yuri K, Fujieda K, Kasagi K, Iida Y, Fujimoto S, FukushiM and Takasugi N : The prediction of thyroid function in infants born to mothers with chronic thyroiditis, Endocrinol.Jap. 36:865-871,1989 Matsuura N, Konishi J, Yuri K, , Harada S, Fujieda K, Nohara Y, Mikami Y, Kasagi K, Iida Y, Hosoda A and Okuno A : Comparison of atrophic and goitrous autoimmune thyroiditis in children : Clinical, laboratory and TSH-receptor antibody studies, Eur J Pediatr 149:529-533, 1990 Tonoki H, Fujieda K, Kajii N, Ozutumi K, Nagano S and Niikawa N : Negative dystrophin staining in muscles of patients with complex glycerol kinase deficiency, J.Pediatr. 117:268-271,　1990 Matsuura N, Konishi J and the Transient Hypothyroidism Study Group in Japan (Fujieda K,et al) : Transient hypothyroidism in infants born to mother with chronic thyroiditis - a nationwide　study of twenty-three cases, Endocrinol Jap 37:369-379,1990 Hosoda A, Fujieda K, Matsuura N, Okuno A and Yuri K : Age related change of pulsatile gonadotropin secretion in Turner syndrome, Pediatr.Res.29:196-200,1991 Nakahori Y, Tamura T, Nagafuchi S, Fujieda K, Minowada S, Fukutani K, Fuse H, Hayashi K, Kuroki Y, Fukushima Y, Agematsu K, Kuno T, Kaneko S, Yamada K, Kitagawa T, Nonomura M, Fukuda S, Kusano M, Onigata S, Hibi I and Nakagome Y : Molecular cloning and mapping of ten new probes on the human Y chromosome, Genomics 9:765-769,1991. Tanaka T, Shizume K, Hibi I, Takano K, Suwa S, Irie M, Okada M, Ogawa M, Okuno A, Kato K, Kono H, Sudo M, Takahara J, Chihara K, Nakajima H, Nishi Y, Hanyu K, Tachibana K, Hirano T and Fujieda K : Growth hormone secretion and the therapeutic effects of human growth hormone : First Japanese results of the Kabi Pharmacia International Growth Study/International Cooperative Growth Study, Acta Paediatr. Scand (Suppl). 379:126-135, 1991 The WHO Multinational Project for Childhood Diabetes Group (Fujieda K,etal) : Familial insulin-dependent diabetes mellitus (IDDM) epidemiology : standardization of data for the DIAMOND Project, Bulletin of the World Health Organization 69:767-777,1991 Tanaka T, Hibi I, Kato K, Saito S, Shimizu N, Suwa S, Nakajima H and the TAP-144-SRCPP Study Group (Fujieda K, et al) : A dose finding study of a superlong-acting luteinizing hormone-releasing hormone analog (Leuprolide Acetate Depot, TAP-144-SR) in the treatment of central precocious puberty, Endocrinol.Jap. 38:369-376,1991. Matsuura N, Fujieda K, Okuno A, Yano K, Ooyanagi K, Mikami Y, Okuno A, Fukuda K: Incidence and prevalence of juvenile-onset IDDM in Hokkaido, Japan, Constitutional Med 55(Suppl):50-53, 1992. Nagafuti S, Tamura T, Nakahori Y, Takano K, Nishi Y, Iwatani N, Kitano M, Hori Y, Konda S, Hasegawa T, Numabe H, Fujieda K, Tanaka T, Hibi I and Nakagome Y : A majority of the marker chromosome in Japanese patients with stigmata of Turner syndrome are derived from Y Chromosomes, Human Genetics 89:590-592,1992 Shigihara-Yasuda K, Tonoki H, Goto Y, Arahata K, Ishikawa N, Kajii N and Fujieda K : Asymptomatic female patient with Duchenne muscular dystrophy diagnosed by dystrophin-staing : a case report, Eur J Pediatr 151:66-68,1992 Tajima T, Fujieda K, Nakayama K and Fujii-Kuriyama Y : Molecular analysis of patient and carrier genes with congenital steroid 21-hydroxylase deficiency by using polymerase chain reaction and single strand conformation polymorphism, J Clin Invest. 92: 2182-2190,1993 Tajima T, Fujieda K and Fujii-Kuriyama Y : Deno vomutation causes steroid 21-hydroxylase deficiency in one family of HLA-identical affected and unaffected siblings, J Clin Endocrinol Metab.77:86-89,1993 Shinohara N, Fujieda K, Nakae J, Tajima T : Analysis on final height in the girls with idiopathic precocious puberty, Clin.Pediatr.Endocrinol.2(Supple):123-126,1993 Aida T, Abe H, Fujieda K, Matsuura N : Endocrine function in children with suprasellar germinoma, Neurologiamedico-chirurgica 33:152-157,1993 Japan IDDM Epidemiology Study Group　(TajimaN, Matsuura N, OkunoA, Fukushima N, Fujieda K, Yano K, Tsutsumi H, Kitagawa T, Urakami A, Sugaya A, Matsushima M, Ohkubo S, Sasaki A, Okamoto Y, Kohno K, La Porte RE) : Lack of regional variationin IDDM risk in Japan, Diabetes Care.16:796-800,1993 Tanaka K, Shimizu N, Imura H, Fukata J, Hibi I, Tanaka T, Nakagawa S, Fujieda K, Takebe K, Yoshinaga K, Takakura K, Suwa S, Tachibana K, Kato K, Yoshimi T, Miura K, Kuwayama A, Ota Z, Kato Y, Saito S, Takahara J, Hashimoto K, Nawata H, Matsukura S, Yanaihara N : Human corticotropin-releasing hormone (CRF) test : Sex and age differences in plasma ACTH and cortisol responses and their reproducibility in healthy adults, Endocrine J.40:571-579, 1993 Tanaka T, Hibi I, Shimizu N, Imura H, Tanaka K, Fukata J, Fujieda K, Ichimura T, Kuribayashi T, Ito K, Suwa S, Tachibana K, Kato K, Ohta M, Yanaihara N : Evaluation of hypothalamo-pituitary-adrenocortical function on children by human corticotropin- releasing hormone (MCI-028) test, Endocrine J 40:581-589,1993 Fujieda K:Pubertal development in Japaneseboys, Clin.Pediatr.Endocrinol, 3(Suppl): 7-14,1993 Fujieda K, Shinohara N, Tajima T, Nakae J : Hypothalamic astrocytoma mimicking hamartoma- A case of report, Clin.Pediatr.Endocrinol.,2:75-79,1993 Pang S, Clark A and co-authors (Fujieda K,et al) : Congenital adrenal hyperplasia due to 21-hydroxylase deficiency : New born screening and its relationship to the diagnosis and treatment of the disorders, Screening 2:105-139,1993 Kato S, Fujimoto M, Hibi I, Suwa S, Shimizu N, Androcur study group in Japan (Fujieda K,et al) : The long-term effect of cyproterone acetate on growth in girls with idiopathic precocious puberty, Eur J Pediatr.152:297-300,1993 Tanaka T, Hibi I, Kato K, Shimizu N, Suwa S, Niimi H and Members of the CPP Clinical Study Group on TAP-144-SR (Fujieda K, et al) : Two-year results of sustained-release Leuprorelin acetate (TAP-144-SR) treatment in children with central precocious puberty, Clin.Pediatr.Endocrinol.2:49-58,1993 Tanaka T, Hibi I, Takano K, Suwa S, Shizume K and the Non-Endocrine Short Stature Study Group (Fujieda K,et al) : One-year growth hormone (GH) treatment in children with non- endocrine short stature, Clin.Pediatr.Endocrinol.2(Supple):33-43,1993 Tanaka T, Hibi I, Takano K, Suwa S, Shizume K and the Non-Endocrine Short Stature Study Group (Fujieda K,et al) : Effect of two-year growth hormone (GH) treatment in children with non-endocrine short stature, Clin.Pediatr.Endocrinol.2:107-117,1993 Koga Y, Fujieda K, Matsumoto Y, Kida T, Tanaka T, Fujimoto S, Nakajima T, Hattori T, Hagisawa M, Kuwajima S, Tahara Y, Nagashima T and Mizumoto M : Gestational age assessment in Japanese low birth weight infants, Acta Pediat.Jap,36:71-74,1994 Nakae J, Shinohara N, Tajima T, Ishikawa N, Yuri K and Fujieda K : Effect of human growth hormone treatment on growth rate and obesity in Prader-Willi Syndrome, Clin Pediatr Endocrinol 3(Supple4):137-143,1994 Tajima T, Nakae J, Shinohara N and Fujieda K : A novel mutation localized in the 3' non-HMG box region of the SRY gene in 46,XY gonadal dysgenesis, Hum Molec Genet 3:1187-1189,1994 Matsumoto K, Iwata S, Takahashi N, Kida T, Makinoda S, Fujimoto S, Nakajima T, Hattori S, Hagisawa M, Koga Y, Tahara Y, Nagashima T, Mizumoto M, Takahashi Y and Fujieda K: Growth in small-for-gestational age and appropriate gestational age low birth weight infants, Clin. Pediatr. Endocrinol. 3(Supple5):1-2,1994 Harada S, Ichihara N, Arai J, Honma H, Matsuura N and Fujieda K : Influence of iodine excess due to iodine-containing antiseptics on neonatal screening for congenital hypothyroidismin, Hokkaido prefecture,Japan, Screening 3:115-123,1994 Tanaka T, Hibi I, Takano K, Suwa S, Shizume K and the Non-Endocrine Short Stature Study Group (Fujieda K,et al) : Three-year results of growth hormone treatment in children with non-endocrine short stature, Clin.Pediatr.Endocrinol 3(Suppl4):27-36,1994 Harada S, Ichihara N, Arai J, Honma H, Matsuura N, Fujieda K, Okuno A, Oyanagi K and Naruse H : Later manifestations of congenital hypothyroidism predicted by slightly elevated thyrotropin levels in neonatal screening, Screening 3:181-192,1995 Tajima T, Fujieda K, Nakae J, Shinohara N, Yoshimoto M, Baba Y, Mtasumoto T, Kinoshita E, Igarashi H, Oomura T : Molecular analysis of type II 3・-hydroxysteroid dehydrogenase gene in Japanese with classical 3・・-hydroxysteroid dehydrogenase deficiency., Hum Molec Genet 4:969-971,1995 Nishi Y, Shizume K, Hibi I, Suwa S, Takano K, Tanaka T, Ogawa M, Fujieda K, Yuri K, Inagawa A, Igarashi U, Watanabe A, Tamura T, Moriya N, Takahashi K, Koyama N, Murata M, Tanae A, Inage K, Miki Y, Anzo M, Yokoya S, Ooyama Y, Ooyama K, Iinuma K, Kagawa J, Ono S, Momoi T, Yamanaka C, Nishimura T, Kubo T, Matsuo K, OoharaK, Yamamoto Y, Gushiken M : Experience in growth hormone therapy in Noonan syndrome in Japan, Clin Pediatr Endocrinol 4(Supple6):67-72,1995 Nakae J, Morioka H, Otsuka E, Fujieda K : Replacement of leucine 87 in human insulin receptor alter affinity for insulin, J Biol Chem 270:22017-22022,1995 Tajima T, Nakae J, Murashita M, Shinohara N, Yuri K, Fujieda K : A novel mutation in the V2 vasopressin receptor gene in two siblings with nephrogenic diabetes insipidus, Clin Pediatr Endocrinol 4:33-37,1995 Harada S, Ichihara N, Fujieda K, Okuno A : Down syndrome with thyroid dysfunction detected by neonatal screening for congenital hypothyroidism, Clin Pediatr Endocrinol 4:115-122,1995 Tonoki H, Nakae J, Tajima T, Shinohara N, Monji J, Satoh S and Fujieda K : Predominance of the mutation at 1138 of the cDNA for the fibroblast growth factor receptor 3 in Japanese patients with achondroplasia, Jap J Hum Gentetics 40:347-349, 1995 Murashita M, Fujieda K, Tajima T, Nakae J, Kato K, Shinohara N : Hyperthyroidism in growth hormone deficient children treated with human growth hormone, Clin Pediatr Endocrinol 4(Supple6):121-126,1995 Endo M, Nagumo A, Yamada Y, Hirose T, Tajima T, Fujieda K : Toxic thyroid nodule with activating point mutation in gene encoding the α subunit of the stimulatory G protein : Case of report, Clin.Pediatr.Endocrinol 4:123-128,1995 Tajima T, Nakae J, Takekoshi Y, Takahashi Y, Yuri K, Nagashima T and Fujieda K : Three novel AVPR2 mutations in three Japanese families with X-linked nephrogenic diabetes insipidus, Pediatr Res,39:1-5,1996 Nishi Y, Fujieda K, Yano K, Yoshizawa A, Kamoda T, Hasegawa Y, Yokoya S, Arisaka O, Tokuhiro E, Yamanaka C, Nose O, Goji K, Araki K, Kinugasa A, Tanaka T, Tezuka T : Elevated adrenocorticotropic hormone-stimulated 17-hydroxypregnenolone/ 17-hydroxy progesterone in Japanese children with premature puberche, hirsutism, acneand /or accelerated growth, Clin Pediatr Endocrinol 5:51-58,1996 Tonoki H, Shinohara N, Nakae J, Tajima T, and Fujieda K : Predominance of the mutation at 1138 of the cDNA for the fibroblast growth fact or receptor 3i n Japanese patients with achondroplasia, Clin Pediatr Endocrionol 5(Supple8):103-104,1996 Fujieda K, Hanew K, Hirano T, Igarashi Y, Nishi Y, Tachibana K, Takano K, Tanaka T, Yokoya S : Growth response to growth hormone therapy in the patients with different extents of growth hormone deficiency, Endocrine J 43(Suppl):S19-S25,1996 Tanaka T, Takano K, Hanew K, Nishi Y, Fujieda K, Tachibana K, Yokoya S, Igarashi Y, Hirano T : Spontaneous growth in growth hormone-treated short children, EndocrineJ 43(Suppl):S135-S136,1996 Nakae J, Tajima T, Kusuda S, Koda N, Okabe T, Shinohara N, Kato M, Murashita M, Mukai T, Imanaka K, Fujieda K : The truncation at the C-terminus of the DAX-1 protein impairs its biological actions in patients with X-linked adrenal hypoplasia congenital, J Clin Endocrinol Metab 81:3680-3685,1996 Hirano T, Takano K, Tanaka T, Hanew K, Igarashi Y, Nishi Y, Fujieda K, Tachibana K, Yokoya S : The relationship between adiposity and height responses during the first two years of growth hormone therapy in prepubertal children with idiopathic growth hormone deficiency, Clin Pediatr Endocrinol 5:67-72,1996 Murashita M, Fujieda K, Tajima T, Nakae J, Kato M and Shinohara N : A boy without growth hormone is growing normally, Clin Pediatr Endocrinol 5:11-16,1996 Tanaka T, Hibi I, Takano K, Suwa S, Shizume K and the Non-Endocrine Short Stature Study Group (Fujieda K,et al) : Four-year experience of growth hormone treatment in children with non-endocrine short stature, Clin Pediatr Endocrinol 5(Supple7):1-9,1996 Bose HS, Sugawara T, JF Strauss III, Miller WL, for the International Congenital Lipoid Adrenal Hyperplasia Consortium (Fujieda K, et al) : The pathophysiology and genetics of congenital lipoid adrenal hyperplasia, N Engl J Med.335:1870-1878,1996 Tajima T, Nishi Y, Takase A, Nakae J, Murashita M, Fujieda K : No genetic alteration of type II 3β-hydroxysteroid dehydrogenase (3βHSD) gene in the patients with biochemical 3βHSD deficiency, Horm Res 47:49-53,1997 Yoshimoto M, Kawaguchi T, Mori R, Kinoshita E, Baba T, Tajima T, Fujieda K, Suzuki T, Sasano H : Pubertal changes in testicular 3・・-hydroxysteroid dehydrogenase activity in a male with classical 3・・-hydroxysteroid dehydrogenase deficiency showing spontaneous secondary maturation, Horm Res 48:83-87,1997 Fujieda K, Tajima T, Nakae J, Sageshima S, Tachibana K, Suwa S, Sugawara T, Strauss JF III : Spontaneous puberty in 46,XX patients with congenital lipoid adrenal hyperplasia : Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic acute regulatory protein (StAR) gene, J Clin Invest 99:1265-1271,1997 Nakae J, Tajima T, Sugawara T, Hanaki K, Hotsubo T, Igarashi N, Igarashi Y, Ishii T, Koda N, Kondo T, Kohno H, Nakagawa Y, Tachibana K, Takeshima Y, Tsubouchi K, Strauss III JF, Fujieda K : Analysis of the steroidogenic acute regulatory protein (StAR) gene, in Japanese patients with congenital lipoid adrenal hyperplasia, Hum Molec Genet 6:571-576, 1997 Mikami A, Yamaguchi A, Fukushi M, Sato Y, Kikuchi Y, Tajima T, Fujieda K : Molecular diagnosis for steroid 21-hydroxylase deficiency by polymerase chain reaction with dried blood spots, Clin Pediatr Endocrinol 6:15-22,1997 Tajima T, Fujieda K, Nakae J, Toyoura T, Shimozawa K, Kusuda S, Goji K, Nagashima T, Cutler Jr,GB : Molecular basis of non classical steroid 21-hydroxylase deficiency detected by neonatal screening in Japan, J Clin Endocrinol Metab 82:2350-2356,1997 Nakae J, Abe S, Tajima T, Shinohara N, Murashita M, Igarashi Y, Kusuda S, Suzuki J, Fujieda K : Three novel frame shift and missense mutations and a de novo deletion mutation of the DAX-1 gene in patients with X-linked adrenal hypoplasia congenita, J Clin Endocrinol Metab 82:3835-3841,1997 Tajima T, Mikami A, Nakae J, Kikuchi Y, Fujieda K : Conventional molecular diagnosis of steroid 21-hydroxylase deficiency using modified polymerase-chain-reaction, Endocrine Res 32:231-244,1997 Abe S, Shinohara N, Nakae J, Tajima T, Murashita M, Inagawa A, Fujieda K : Experience with growth hormone therapy in a patient with osteogenesis imperfecta, Clin Pediatr Endocrinol 6(Suppl9):73-76,1997 Fujieda K, Matsumoto Y, Shinohara N, Kato M, Murashita M, Tajima T, Nakae J : Basic and clinical aspects of IUGR, Clin Pediatr Endocrinol 6:(Supple10):115-121,1997 Tanaka T, Niimi H, Matsuo N, Fujieda K, Tachibana K, Ohyama K, Satoh M, Hibi I : Dose of LHRH analog and growth velocity influence predicted final height in girls with central precocious puberty, Clin Pedicatr Endocrionol 6:77-84,1997 Nilsson C, Pettersson K, Millar RP, Coerver K, Matzuk MM, Huhtaniemi IT on behalf of the International Collaborative Research Group (Fujieda K,et al) : World-wide frequency of a common genetic variant of LH, Fertility and Sterility 67:998-1004,1997 Nakae J, Kato M, Shinohara N, Murashita M, Tajima T, Fujieda K : Long-term effect of recombinant human insulin-like growth factor I on metabolic and growth control in a patient with leprechaunism, J Clin Endocrinol Metab 83:542-549,1998 Sawamura Y, Shirato H, Ikeda J, Tada M, Ishii N, Kato T, Abe H, Fujieda K : Induction chemotherapy followed by reduced-volume irradiation for newly diagnosed CNS germinoma, J Neurosurg 88:66-72,1998 Imamura Y, Fujieda K, Tajima T, Yamazaki T, Miyabayashi M, Mori T, Komiyama A : Non classical 21-hydroxylase deficiency detected by new born mass screening program for congenital adrenal hyperplasia (CAH) : Report of a case , Clin Pediatr Endocrinol 7:35-40, 1998 Igarashi Y, Tanaka T, Fujieda K, Hanew K, Hirano T, Takano K, Yokoya S, Tachibana K, Nishi Y : Growth hormone treatment in patients with intrauterine growth retardation : Comparison of growth response with that in growth hormone deficient children, Clin Pediatr Endocrinol 7(Supple11):55-61,1998 Hanew K, Tanaka T, Fujieda K, Igarashi K, Hirano T, Takano K, Yokoya S, Tachibana K, Nishi Y : Factors determining the effectiveness of hGH treatment in patients with Turner syndrome, Clin Pediatr Endocrinol 7(Supple11):63-67,1998 Murashita M, Satoh K, Abe S, Nakae J, Tajima T, Shinohara N, Fujieda K: Clinical course of hyperthyroidism in three growth hormone deficient children treated with growth hormone, Clin Pediatr Endocrinol 7(Supple11):85-88,1998 Tajima T, Fujieda K, Mikami A, Igarashi H, Nakae J, CutlerJr.GB : Prenatal diagnosis of steroid 21-hydroxylase deficiency by the modified polymerase chain reaction to detect splice site mutation in the CYP21 gene, Endocrine J 45:291-295,1998 Nishi Y, Tanaka T, Fujieda K, Hanew K, Hirano T, Igarashi Y, Tachibana K, Yokoya S, Takano K : Slipped capital femoral epiphysis, Perthes' disease and scoliosis in children with growth hormone deficiency, Endocrine J 45(Suppl):S167-S169,1998 Ohyama K, Tanaka T, Tachibana K, Niimi H, Fujieda K, Matsuo N, Satoh M, Hibi I : Timing for discontinuation of treatment with along-acting gonadotropin-releasing hormone analog in girls with central precocious puberty, Endocrine J 54:351-356,1998 Tajima T, Fujieda K, Nakae J, Mikami A, Cutler GB,Jr : Mutations of the CYP21 gene in non classical steroid 21-hydroxylase deficiency in Japan, Endocrine J 45:493-497,1998 Kato I, Sawamura Y, Tada M, Murata J, Abe H, Shirato H, Fujieda K : Occult neurohypophyseal germinomas in patients presenting with central diabetes insipidus, Neurosurgical Focus 5:1-6,1998 Tanaka T, Takano K, Hanew K, Nishi Y, Igarashi Y, Hirano T, Saito T, Tachibana K, Yokoya S, Fujieda K, Shimatsu A, Hizuka N, Tsushima T, Irie M : Registration system for growth hormone (GH) treatment with standardized immunoreactive GH values in Japan, Endocrine J 45:459-465,1998 Hoshi N, Fujita M, Mikuni M, Fujino T, Okuyama K, Handa Y, Yamada H, Sagawa T, Hareyama H, Nakahori Y, Fujieda K, Kant JA, Nagashima K, Fujimoto S : Seminoma in a postmenopausal woman who demonstrated a Y;15translocation in peripheral blood lympocytes, and at(Y;15)/45,X Turner mosaic pattern in skin fibroblasts, J Med Genet 35:852-856,1998 Kosugi S, Sato Y, Matsuda A, Ohyama Y, Fujieda K, Inomata H, Kameya T, Isozaki O, Jhiang SM : High prevalence of T354P sodium/iodide symporter gene mutation in Japanese patients with iodide transport defect who have heterogeneous clinical pictures, J Clin Endocrinol Metab 83:4123-4129,1998 Kaji M, Tanaka Y, Kim S-H, Kurosaki K, Kawasaki T, Saito A, Nakae J, Fujieda K : A case of congenital lipoid adrenal hyperplasia associated with dilated cardiomyopathy, Clin Pediatr Endocrinol 7:99-103,1998 Yamano K, Ichihara N, Terai I, Arai J, Harada S, Fujimoto S, Fujieda K ,Kudo R, Kudoh T, Ishikawa M, Okuno A : Effects of screening for thyroidysfunction in pregnant women, linked to neonatal screening for congenital hypothyroidism, Clin Pediatr Endocrinol 7:115-123,1998 Hoshi N, Tonoki H, Handa Y,Fujino T, Okuyama K, Koga Y, Matsumoto Y, Yamada T, Yamada H, Kishida T, Sagawa T, Fujieda K, Nakahori Y, Kant JA, Fujimoto S : Prenatal identification of mos45,X/46.X+mar in a normal male baby by cytogenetic and molecular analysis, Prenatal Diag,18:1316-1322,1998 Abe S, Nakae J, Yasoshima K, Tajima T, Shinohara N, Murashita M, Satoh K, Koike A, Takahashi Y, Fujieda K : A novel missense mutation (Leu466Arg) of the DAX-1 gene in a patient with X-linked adrenal hypoplasia congenital, Am J Med Genet 84:87-89,1999 Yokoya S, Araki K, Igarashi Y, Kohno H, Nishi Y, Hasegawa Y, Fujita K, Iwatani N, Tachibana K, Ohyama Y, Seino Y, Satoh M, Fujieda K, Tanaka T : Advantage of higher growth hormone (GH) dosage on prepubertal growth in GH deficient children, Acta Paediatrica (Suppl) 428:79-79,1999 Nishi Y, Tanaka T, Takano K, Fujieda K, Igarashi Y, Hanew K, Hirano T, Yokoya S, Tachibana K, Saito T : Recent status in the occurrence of leukemia in growth hormone-treated patients in Japan, J Clin Endocrinol Metab 84:1961-1965,1999 Takano K, Tanaka T, Fujieda K, Hanew K, Hirano T, Igarashi Y, Nishi Y, Tachibana K, Yokoya S, Tanizawa T : Final height in GHD children with GH treatment, Clin Pediatr Endocrinol 8(Supple12):29-35,1999 Tanaka T, Takano K, Igarashi Y, Hanew K, Nishi Y, Tachibana K, Hirano T, Fujieda K, Yokoya S, Tanizawa T : Growth hormone (GH) treatment and puberty in GH-treated GH deficient children, Clin Pediatr Endocrinol 8(Supple12):37-44, 1999 Tachibana K, Tanaka T, Takano K, Fujieda K, Hanew K, Igarashi Y, Hirano T, Yokoya S, Tanizawa T, Nishi Y : Analysis of poor responders to short term groth hormone treatment, Clin Pediatr Endocrinol 8(Supple12):45-54,1999 Yokoya S, Tanaka T, Fujieda K, Hanew K, Igarashi Y, Hirano T, Takano K, Tachibana K, Nishi Y : Adverse drug reactions during growth hormone therapy from the Internatinal Cooperative Growth Study (ICGS) database, Clin Pediatr Endocrinol 8 (Supple12) :107-114, 1999 Tachibana K, Tanaka T, Takano K, Fujieda K, Igarashi Y, Hirano T, Yokoya S, Nishi Y, Hanew K, Tanizawa T : Analysis of demographic data of registered children, Clin Pediatr Endocrinol 8(Supple13):15-21,1999 Fujieda K, Hanew K, Hirano T, Igarashi Y, Nishi Y, Tachibana K, Takano K, Tanaka T, Yokoya S : Three-year growth response to growth hormone therapy in patients with different degrees of growth hormone deficiency : Analysis of the Japanese International Cooperative Growth Study, Clin Pediatr Endocrinol 8(Supple13):15-21,1999 Takano K, Tanaka T, Fujieda K, Hanew K, Hirano T, Igarashi Y, Nishi Y, Tachibana K, Yokoya S, Tanizawa T : Final height achieved with GH treatment in cases of short stature due to GH secretion deficiency-Ten years of recent cases, Clin Pediatr Endocrinol 8 (Supple13):29-35,1999 Nishi Y, Tanaka T, Takano K, Fujieda K, Igarashi Y, Hanew K, Hirano T, Yokoya S, Tachibana K, Saito T, Watanabe S : Status in which leukemia arises in growth hormone treated patients, Clin Pediatr Endocrinol 8(Supple13):79-84,1999 Okuhara K, Shinohara N, Abe S, Sato K, Nakae J, Tajima T, Fujieda K : A 8 year-old girl with severe growth failure due to hypertrophic pyloric stenosis (HPS) : Report of a case, Clin Pediatr Endocrinol 8(Supple12):131-133,1999 Okuhara K, Tajima T, Nakae J, Sasaki S, Tochimaru H, Abe S, Fujieda K : A Japanese case with Frasier syndrome caused by the splicing junction mutation of WT-1gene, Endocrine J 46:639-642,1999 Murashita M, Tajima T, Nakae J, Shinohra N, Geffner ME, Fujieda K : Near-normal linear growth in the setting of markedly reduced growth hormone and IGF-I, Horm Res 51:184-188,1999 Hirano T, Takano K, Tanaka T, Hanew K, Igarashi Y, Nishi Y, Fujieda K, Tachibana K, Yokoya S : Height responses in complete idiopathic growth hormone deficient children less than three years of age during growth hormone therapy, Endocrine J 46(Suppl):S1-S4,1999 Tanaka T, Seino Y, Fujieda K, Igarashi Y, Yokoya S, Tachibana K, Ogawa Y : Pharmacokinetics and metabolic effects of high-dose growth hormones administration in healthy adult men, Endocrine J 46:605-612,1999 Mori Y, Jing P, Kayama M, Fujieda K, Hasegawa T, Nogimori T, Hirooka Y, Mitsuma T : Gene amplification as a common cause of inherited thyroxine-binding globulin excess : Analysis of one familial and two sporadic cases, Endocrine J 46:613-619,1999 Abo K, Sumino K, Nisjio H, Hozumi T, Ishida Y, Fujieda K, Tajima T, Kazumi T : Nonclassic 21-hydroxylase deficiency presenting as bilateral adrenal tumors in the seventh decade of life, Endocrine J 46:817-823,1999 Mikami A, Fukushi M, Oda H, Fujita K, Fujieda K : Newborn screening for congenital adrenal hyperplasia in Sapporocity : Sixteen years experience, Southeast Asian J Trop Med Public Health 30(Suppl2):100-102,1999 Okuhara K, Tajima T, Abe S, Satoh K, Nakae J, Shinohara N, Fujieda K : Gonadotropin-releasing hormone analog therapy failure to improve predicted final height in two children with central precocious puberty and microcephalus, Endocrine J 47(Suppl): S129-S132,2000 Okuhara K, Tajima T, Nakae J, Fujieda K : A novel missense mutation in the HMG box region of the SRY gene in a Japanese patient with a XY sex reversal, J Hum Genet 45:112-114,2000 Tanaka T, Matsuo N, Seino Y, Fujieda K, Yokoya S, Tachibana K, the Study Group of GH Treatment in IUGR : Growth-promoting and psychological effects of high-dose growth hormone treatment in children with intrauterine growth retardation, Clin Pediatr Endocrinol 9:7-17,2000 Hizukuri K, Ono S, Masuda R, Mizota K, Nikaido K, Otsubo K, Eto S, Tamada I, Fukami S, Fujieda K : A false negative case with 21-hydroxylase deficiency at newborn mass screening program-Case report and review of the mass screening program in Kagoshima Prefecture-, Clin Pediatr Endocrinol 9:25-30,2000 Sato K, Tajima T, Nakae J, Adachi M, Asakura Y, Tachibana K, Suwa S, Katsumata N, Tanaka T, Hayashi Y, Abe S, Murashita M, Okuhara K, Shinohara N, Fujieda K : Three novel PHEX gene mutations in Japanese patients with X-linked hypophosphatemic rickets, Pediatr Res 48:536-540,2000 Endo M, Yasoshima K, Ishizaki S, Ishizaka S, Nawate M, Matsuzaki T, Shinohara N, Fujieda K : Development of central precocious puberty after surgical resection in a boy with cranipharyngioma : Case report, Clin Pediatr Endocrinol 9:63-67,2000 Tajima T, Kitagawa H, Yokoya S, Tachibana K, Adachi M, Nakae J, Suwa S, KatohS, Fujieda K : A novel missense mutation of mineralcorticoid receptor gene in one Japanese family with a renal form of pseudohypoaldosteronism typeI, J Clin Endocrinol Metab 85:4690-4694, 2000 Sato N, Ishikawa M, Nimura A, Katsumata N, Horikawa R, Tanae A, Tanaka T, Matsuo N, Seino Y, Fujieda K, Yokoya S, Tachibana K, Shimizu N, Study Group of GH Treatment in IUGR : Growth hormone (GH) binding protein in children with high dose GH, Clin Pediatr Endocrinol 9:(Suppl14):55-61,2000 Sato K, Tajima T, Nakae J, Abe S, Okuhara K, Fujieda K : Evaluation of bone mineral density in patients with Turner syndrome, Clin Pediatr Endocrinol 9:(Suppl 14):55-61,2000 GH Research Society (Fujieda K, et al) : Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence : Summary statement of the GH Research Society, J Clin Endorionol Metab 85:3990-3993,2000 Adachi M, Tachibana K, Asakura Y, Abe S, Nakae J, Tajima T, Fujieda K: Compound heterozygous mutations in the γsubunit gene of ENaC (1627 delG and 1570-1G→A) in one sporadic Japanese patient with a systemic form of pseudohypoaldosteronism type 1. J Clin Endocrinol Metab, 86:9-12, 2001 Ishikawa Y, Tajima T, Nakae J, Nagashima T, Satoh K, Okuhara K, Fujieda K:Two mutations of Gs・ gene in two sporadic Japanese patients with pseudohypoparathyroidism type Ia. J Hum Genet, 46:426-430, 2001 Tajima T, Fujieda K, Kouda N, Nakae J, Miller WL:Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46, XY sex reversal and adrenal insufficiency. J Clin Endcrionol Metab, 86:3820-3825, 2001 Lebl J, Fujieda K, Kalvachova B, Votava F:A boy with adrenal insufficiency and DAX-1 gene defect, Diabetologie Metabolismus Endokrinologie Vyziva 4,2:136-139, 2001 Sugawara T, Abe S, Sakuragi N, Fujimoto Y, Nomura E, Fujieda K, Saito M, Fujimoto S: RIP140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1. Endocrinology 142:3570-3577, 2001 Tajima T, Oishi M, Nakae J, Satoh K, Okuhara K, Kanaya Y, Fujieda K:Turner syndrome and Crohn disease. Clin Pediatr Endocrinol 10:137-140, 2001 Kawamura M, Owada M, Kimura Y, Fujiwara T, Sasaki A, Tajima T, Fujieda K, Hiramori K:46,XY pure gonadal dysgensis: A case with Graves' disease and exceptionally tall stature.Internal Medicine 40:740-743, 2001 Adachi M, Tachibana K, Asakura Y, Abe S, Nakae J, Tajima T, Fujieda K : Compound heterozygous mutations in the gamma subunit gene of ENaC (1627delG and 1570-1G-->A)in one sporadic Japanese patient with a systemic form of pseudohypoaldosteronism type 1. J Clin Endocrinol Metab.;86(1):9-12. 2001 Ishikawa Y, Tajima T, Nakae J, Nagashima T, Satoh K, Okuhara K, Fujieda K :Two mutations of the Gsalpha gene in two Japanese patients with sporad pseudohypoparathyroidismtype Ia. J Hum Genet.;46(7):426-30. 2001 Tajima T, Fujieda K, Kouda N, Nakae J, Miller WL : Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency. J Clin Endocrinol Metab. 86(8):3820-5. 2001 Aoyama H, Shirato H, Ikeda J, Fujieda K, Miyasaka K, Sawamura Y: Induction chemotherapyfollowed by low-dose involed-field radiothe rapy for intracranial germ cell tumors. J Clin Oncology 20:857-86 5, 2002. Tajima T, Kobayashi Y, Abe S, Takahashi M, Konno M, Nakae J, Okuh ara K, Satoh K, Ishikawa T, Imai T, Fujieda K:Two novel mutations of thiazide-sensitive Na-Cl cotransporter(TSC) gene in two sporad ic Japanese patients with Gitelman syndrome Endocrine J 49:91-96, 2002. Sato K, Hasegawa Y, Nakae J, Nanao K, Takahashi I, Tajima T, Shin ohara N, Fujieda K: Hydrochlorothiazide effectively reduces urina ry calcium excretion in two Japanese patients with gain-of-functi on mutations of the calcium-sensing receptor gene. J Clin Endocri nol Metab 87:3068-3073, 2002. Nonomura K, Kakizaki H, Fukuzawa N, Fujieda K, Niikawa N, Koyanag i T: Monozygotic twins with discordant sexual phenotypes due to different ratios of mosaicism of 47,X, idic (Y), idic (Y)/46,X, i dic(Y)/45,X. Endocrine J 49:497-501, 2002. Mukai T, Kusaka M, Kawabe K, Goto K, Nawata H, Fujieda K, Morohas hi K: Sexually dimorphicexpression of Dax-1 in the adrenal gland. Genes to Cells 7: 717-729, 2002. Joint LWPES/ESPE CAH Working Group (Fujieda K, et al): Consensus statement on 21-hydroxylase deficiency from the Lawson Wilkins Pe diatric Endocrine Society and the European Society for Paediatric Endocrinology. J Clin Endocrinol Metab 87:4048-4053, 2002. Tajima T, Hattori T, Nakajima T, Okuhara K, Sato K, Abe S, Nakae J, Fujieda K: Sporadic heterozygous frameshift mutation of HESX1 causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese patient. J Clin Endocrinol Metab. 88:45-50, 2003 Kawajiri K, Ikuta T, Suzuki T, Kusaka M, Muramatsu M, Fujieda K, Tachibana M, Morohashi K: Role of the LXXLL-motif and AF2 domain in subcellular localization of Dax-1. Mol Endocrinol. 17:994-1004, 2003 Tajima T, Okuhara K, Satoh K, Nakae J, Fujieda K: Two novel aquaporin-2 mutations in a sporadic Japanese patient with autosomal recessive nephrogenic diabetes insipidus. Endocrine J. 50:473-476, 2003 Ogawa E, Fujieda K, Tachibana K, Inomata H, Kinoshita E, Kusuda S, Nishi M, Okada T, Saisho S, Tajima T, Tanaka T: Mortality in patients with congenital 21-hydroxylase deficiency diagnosed after the implitation of a newborn screening program in Japan. Clin Pediatr Endocrinol. 12:19-23, 2003 Takezaki T, Nakai S, Tajima T, Okuhara K, Satoh K, Iwasaki Y, Fujieda K: A case of achondroplasia associated with cervicomedullary-junction compression. Clin Pediatr Endocrinol. 12:39-42, 2003 Tajima T, Sasaki S, Tanaka Y, Kusunoki H, Nagashima T, Nonomura K, Fujieda K: 46, XY phenotypic male with focal segmental glomeruloscrerosis caused by the WT1 splice site mutation. Horm Res. 60:302-305, 2003 Ueda O, Fujine M, Mukai T, Ito Y, Fujieda K: A male patient with severe growth retardation, immunodeficiency and diabetes mellitus: a new syndrome? Clin Pediatr Endocrinol. 12(Suppl 20): 47-49, 2003 Tajima T, Nakae J, Fujieda K: Two heterozygous mutations of CLDN16 in a Japanese patient with FHHNC. Pediatr Nephrol. 18:1280-1282, 2003 Zimmermann MB, Hess SY, Moloanari L, de Benoist B, Delange F, Braveman L, Fujieda K, Ito Y, Jooste PL, Moosa K, Pearce E, Pretell EA, Shishiba Y: New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for health and development iodine deficiency study group report. Am J Clin Nutr. 79:231-237, 2004 Fluck C, Tajima T, Pandey AV, Arlt W, Okuhara K, Verge CF, Jabs EW, Mendoca BB, Fujieda K, Miller WL: Mutant P450-oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. Nature Genet. 36:228-230, 2004 Shirato H, Aoyama H, Ikeda J, Fujieda K, Kato N, Ishi N, Miyasaka K, Iwasaki Y, Sawamura Y: Impact of margin for target volume in low-dose involved field radiotherapy after induction chemotherapy for intracranial germinoma. Int J Radiat Oncol Biol Phys. 60:214-217, 2004 Tanaka T, Niimi H, Matsuo N, Fujieda K, Tachibana K, Ohyama K, Satoh M, Kugu K: Results of long-term follow-up after treatment of central precocious puberty with leuprorelin acetate: Evaluation of effectiveness of treatment and recovery of gonadal function. J Clin Endocrinol Metab. 90:1371-1376, 2005 Hanew K, Tachibana K, Yokoya S, Fujieda K, Tanaka T, Igarashi Y, Shimatsu A, Tanaka H, Tanizawa T, Teramoto A, Nishi Y, Hasegawa Y, Hizuka N, Hirano T, Fujita K: Studies of very severe short stature with severe GH deficiency: From the data registered with the Foundation for Growth Science. Endocrine J. 52:37-43, 2005 Zimmermann MB, Ito Y, Hess SY, Fujieda K, Molinari L: High thyroid volume in children with high dietary iodine intake. Am J Clin Nutr. 81:840-844, 2005 Tajima T, Satoh K, Okuhara K, Tsubaki J, Fujieda K: Hypomagnesemia in a patient with Barth syndrome. J Pediatr Endocrinol Metab. 18:523, 2005 Tajima T, Tsubaki J, Fujieda K: Two novel mutations in the thyroid peroxidase gene with goitrous hypothyroidis. Endocr J. 52:643-645, 2005 Tanaka T, Tachibana K, Shimatsu A, Katsumata N, Tsushima T, Hizuka N, Fujieda K, Yokoya S, Irie M: A nationwide attempt to standardize growth hormone assays. Horm Res. 64(Supple2):6-11, 2005 Suzuki S, Mukai T, Uetake K, Sageshima S, Matsuo K, Ueda O, Ito Y, Fujieda K: Permanent Neonatal Diabetes Mellitus with Growth Disturbance, Developmental Delay, Epilepsy and Dysmorphic Features. Clin Pediatr Endocrinol. 14(suppl 24):81-84, 2005 Kagami-Takasugi M, Katsumata N, Tanaka T, Tajima T, Fujieda K:Molecular genetic analysis of MODY candidate genes in Japanese patients with non-obese juvenile onset diabetes mellitus. J Pediatr Endocrinol Metab 19:143-148, 2006 Tanaka T, Fujieda K, Yokoya S, Shimatsu A, Tachibana K, Tanaka H, Tanizawa T, Teramoto A, Nagai T, Nishi Y, Hasegawa Y, Hanew K, Fujita K, Horikawa R, Takada G, Hasegawa Y, Ohno T, Komatsu K:No improvement of adult height in non-growth hormone (GH) deficient short children with GH treatment. Clin Pediatr Endocrinol 15:15-21, 2006 Saito T, Tachibana K, Shimazu A, Katsumata N, Hizuka N, Fujieda K, Yokoya S, Tanaka T:Standardization of blood growth hormone levels measured by different kits using linear structural relationship. Clin Pediatr Endocrinol, 15:79-84, 2006 Hanew K, Tachibana K, Yokoya S, Fujieda K, Tanaka T, Igarashi Y, Shimatsu A, Tanaka H, Tanizawa T, Teramoto A, Nishi Y, Hasegawa Y, Hizuka N, Hirano T, Fujita K:Clinical characteristics, etiologies and pathophysiology of patients with severe short stature with severe GH deficiency:Questionnaire study on the data registered with the foundation for growth science, Japan, Endocrine J 53:259-265, 2006 Tajima T, Nawate M, Takahashi Y, Mizoguchi Y, Sugihara S, Yoshimoto M, Murakami M, Adachi M, Tachibana K, Mochizuki H, Fujieda K:Molecular analysis of the CLCNKB gene in Japanese patients with classic Bartter syndrome. Endocr J 53:647-652, 2006 Ito Y, Fujieda K, Tanaka T, Takano K, Chihara K, Seino Y, Irie M:Low-dose growth hormone treatment (0.175 mg/kg/week) for short stature in patients with Turner syndrome: Data from KIGS Japan. Endocr J 53:699-703, 2006 Savage MO, Cassorla FG, Gluckman PD, Gruters-Kieslich A, Raghupathy P, Silink M, Czernichow P, Chiarelli F, Rogol AD, Crock PA, Cowell CT, Fujieda K, Arnhold IJ: International Societies for Paediatric Endocrinology: Global inequalities in paediatric endocrine practice:statement of minimal acceptable care. Statement from the International Societies for Paediatric Endocrinology. Horm Res 65:111-113, 2006 Tanaka H, Amamiya S, Miura N, Araki A, Ohinata J, Fujieda K: Postnatal development of brainstem serotonin-containing neurons projecting to lumbar spinal cord in rats. Brain Dev 28: 586-591, 2006. Hughes IA, Houk C, Ahmed SF, Lee PA, LWPES/ESPE Consensus Group (Fujieda K, et al):Consensus statement on management of intersex disorders, Arch Dis Child 91:554-563, 2006 Ogawa H, Suzutani T,Baba Y, Koyano S, Nozawa N, Ishibashi K, Fujeida K, Inoue N, Omori K:Etiology of severe sensorineural hearing loss in children: independent impact of conenital cytomegalovirus infection and GJB2 mutations. J Infect Dis 195:782-788, 2007 Makita Y, Narumi Y, Yoshida M, Niihori T, Kure S, Fujieda K, Matsubara Y, Aoki Y:Leukemia in Cardio-facio-cutaneous (CFC) syndrome: a patient with a germline mutation in BRAF proto-oncogene. J Pediatr Hematol Oncol 29:287-290, 2007 Tajima T, Hattori T, Nakajima T, Okuhara K, Tsubaki J, Fujieda K:A novel missense mutation (P366T) of the LHX4 gene causes severe combined pituitary hormone deficiency with pituitary hypoplasia, ectopic posterior lobe and a poorly developed sella turcica. Endocr J 54:637-634, 2007 Suzuki S, Makita Y, Mukai T, Matsuo K, Ueda O, Fujieda K:Molecuklar basis of neonatal diabetes in Japanese patients. J Clin Endocrinol Metab, 92:3979-3985,2007 Tajima T, Fujiwara F, Sudo A, Saito S, Fujieda K: A Japanese patient of congenital hypothyroidism with cerebellar atrophy. Endocr J. 54(6):941-944, 2007 Adachi M, Asakura Y, Sato Y, Tajima T, Nakajima T, Yamamoto T, Fujieda K: Novel SLC12A1 (NKCC2) mutations in two families with Bartter syndrome Type 1. Endocr J. 54(6):1003-1007, 2007 Okuhara K, Abe S, Kondo T, Fujita K, Koda N, Mochizuki H, Fujieda K, Tajima T: Four Japanese patients with adrenal hypoplasia congenital and hypogonadotropic hypogonadism caused by DAX-1 gene mutations:Mutant DAX-1 failed to repress steroidogenic acute regulatory protein (StAR) and luteinizing hormone β-subunit gene promoter activity. Endocr J, in press Tanaka T, Fujieda K, Yokoya S, Tada H, Mishina J, Seino Y:Efficacy and safety of Growth Hormone (GH) of short children born SGA in Japan. J Pediatr Endocrinol Metab, in press Ohinata J, Suzuki N, Araki A, Takahashi S, Fujieda K, Tanaka H: Actigraphic assessment of sleep disorders in children with chronic fatigue syndrome, Brain Dev, in press Takahashi S, Ohinata J, Makita Y, Suzuki N, Araki A, Sasaki A, Murono K, Tanaka H, Fujieda K: Skewed X chromosome inactivation failed to explain the normal phenotype of a carrier female with MECP2 mutation resulting in Rett syndrome, Clin Genet 2007, in press Okamoto T, Takahashi S, Nakamura E, Nagaya K, Hayashi T, Shirai M, Fujieda K: Increased matrix metalloproteinase-9 activity in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus. Ear Hum Dev; in press

英文業績　─ 総説 ─

Inomata H, Matsuura N, Tachibana K, Kusuda S, Fukushi M, Umehashi H, Suwa S, NiimiH, Fujieda K : Guideline for neonatal mass-screening for congenital hypothyroidism, Clin Pediatr Endocrinol 8:51-55, 1999 Saisho S, Yokota I, Kusuda S, Tachibana K, Igarashi Y, Suwa S, Umehashi T, Fukushi M, Fujieda K : Guidelines for diagnosis steroid 21-hydroxylase deficiency, Clin Pediatr Endocrinol 8:57-60, 1999 Kusuda S, Tachibana K, Saisho S, Yokota I, Igarashi Y, Suwa S, Fujieda K : Guideline for treatment of patients with 21-OHase deficiency detected by neonatal screening (Revised in 1999), Clin Pediatr Endocrinol 8:61-65, 1999 Joint LWPES/ESPE CAH Working Group (Fujieda K, et al): Consensus statement on 21hydroxylase deficiency from the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology. J Clin Endocrinol Metab. 87:4048-4053, 2002 Fujieda K, Okuhara K, Abe S, Tajima T, Mukai T, Nakae J: Molecular pathogenesis of lipoid adrenal hyperplasia and adrenal hypoplasia congenital. J Steroid Biochem & Mol Biol. 85:483-489, 2003 Pandey AV, Fluck CE, Huang N, Tajima T, Fujieda K, Miller WL: P450 oxidoreductase deficiency: a new disorder of steroidogenesis affecting all microsomal P450 enzymes. Endocr Res. 30:881-888, 2004 Fujieda K, Tajima T: Molecular basis of adrenal insufficiency. Pediatr Res. 57:62R-69R, 2005