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神経グループは田中肇講師、高橋悟助教、荒木章子講師、大日向純子医員、鈴木菜生医員、の５名で構成されております。診療面ではてんかん、脳性麻痺、変性疾患、筋疾患などの診療に加え、平成19年6月より「子どもの発達診療センター」が開設され、荒木講師、大日向医員に菅野絵里子心理士を加えた三名が中心となって自閉症，ADHD、学習障害などの発達障害や、不登校などの心身症診療にあたっております。また当グループは関連病院や児童相談所などの神経専門外来や相談業務も数多く抱え、地域と連携した診療を目指し努力しております。研究面では、高橋助教が中心となり脳形成異常の病態解明など分子生物学的手法を用いた研究を活発に行っている一方、事象関連電位や光トポグラフィーを用いた発達障害児の高次機能評価、障害児や慢性疲労症候群児の睡眠リズム，生体リズム解析などを中心とした臨床研究にも精力的に取り組んでおります。
●スタッフ●
- 田中肇；講師（日本小児科学会専門医、小児神経学会専門医、日本睡眠学会認定医）
- 高橋悟；助教(日本小児科学会専門医）
- 荒木章子；講師（日本小児科学会専門医、小児神経学会専門医、日本臨床神経生理学会認定医）
- 大日向純子；医員（日本小児科学会専門医）
- 鈴木菜生；医員（日本小児科学会専門医）
●研究テーマ●
- 低酸素性脳症の病態解明-５HT神経系に与える影響と予防法の検討
- 脳形成異常の病態解明-前脳特異的Cdk5欠損マウスをモデルとして
- Glut-1欠損症の診断と病態解明
- インフルエンザ脳症の病態解明
- 早産低出生体重児の酸化ストレスとメラトニン分泌の検討
- 光トポグラフィーによる注意および反応行動抑制障害の評価
- 睡眠障害を呈する児に対するアクチグラフを用いた評価と酸化傷害の検討
- 慢性睡眠不足が脳組織に及ぼす影響に関する検討
●取得した専門医研修施設●
●業 績●
- Inoue K, Tanaka H, Scaglia F, Araki A, Shaffer LG, Lupski JR: Compensating for central nervous system dysmyelination: femals with a proteolipid protein gene duplication and sustained clinical improvement, Ann Neurol, 50: 747-754, 2001
- Amiel J, Espinosa-Parrilla Y, Stefann J, Gosset P, Pelet A, Prieur M, Boute O, Choiset A, Lacombe D, Philip N, Le Merrer M, Tanaka H, Till M, Touraine R, Toutain A, Vekemans M, Munnich A, Lyonnet S. Large-scale deletions and SMADIP1 truncating mutations in syndromic hirschsprung disease with involvement of midline structures, Am J Hum Genet, 69: 1370-1377, 2001
- Takemitsu M, Mishima R, Torii T, Oka R, Tanaka H, Araki A, Cho K: The usefulness of a new electric power assist unit for wheelchairs for patients with Duchenne muscular dystrophy, The First ISPRM Congress, Amsterdam (The Netherlands); (July7-13): 543-546, 2001
- Takahashi S, Ohsugi K, Yamamoto T, Shiomi M, Sakuragawa N: A novel approach to ex vivo gene therapy for familial hypercholesterolemia using human amniotic epithelial cells as a transgene carrier. Tohoku J Exp Med 193: 279-292, 2001
- Kosuga M, Takahashi S, Tanabe A, Fujino M, Li XK, Suzuki S, Yamada M, Kakishita K, Ono F, Sakuragawa N, Okuyama T: Widespread distribution of adenovirus-transduced monkey amniotic epithelial cells after local intracerebral injection: implication for cell-mediated therapy for lysosome storage disorders. Cell Transplant 10: 435-439, 2001
- Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH: p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 21: 6758-6771, 2001
- Li BS, Sun MK, Zhang L, Takahashi S, Ma W, Vinade L, Kulkarni AB, Brady RO, Pant HC: Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc Natl Acad Sci USA 98: 12742-12747, 2001
- Li BS, Zhang L, Takahashi S, Ma W, Jaffe H, Kulkarni AB, Pant HC: Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J 21: 324-333, 2002
- Ohshima T, Ogawa M, Takeuchi K, Takahashi S, Kulkarni AB, Mikoshiba K: Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain. J Neurosci 22: 4036-4044, 2002
- Takahashi S, Saito T, Hisanaga S, Pant HC, Kulkarni AB: Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J Biol Chem 278: 10506-10515, 2003
- Li BS, Ma W, Jaffe H, Zheng Y, Takahashi S, Zhang L, Kulkarni AB, Pant HC: Cdk5 is involved in neuregulin-dependent activation of PI-3 kinase and Akt activity mediating neuronal survival. J Biol Chem,278: 35702-35709, 2003
- Tanaka H, Habaguchi T, Nagaoka Y, Oki J, Takakusaki K: Effect of melatonin and diazepam on eye movement and postural muscle tone in decerebrate cats, Sleep and Biological Rhythms, 1: 203-208, 2003
- Koyano S, Araki A, Hirano Y, Fujieda K, Suzutani T, Tagyu K, Murono K, Inoue N：Retrospective diagnosis of congenital cytomegalovirus infection using dried umbilical cords.Pediatr Infect Dis J.23:481-2、2004
- Hirasawa M, Ohshima T, Takahashi S, Veeranna, Pant HC, Mikoshiba K, Brady RO and Kulkarni AB: Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc. Natl. Acad. Sci. USA 101:6249-6254, 2004.
- Kesavapany S, Amin N, Zheng YL, Nijhara R, Jaffe H, Sihag R, Gutkind JS, Takahashi S, Kulkarni AB, Grant P and Pant HC: p35/cyclin-dependent kinase 5 phosphorylation of Ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons. J Neurosci 24: 4421-4431, 2004.
- Griffin SV, Hiromura K, Pippin J, Petermann AT, Blonski MJ, Krofft R, Takahashi S, Kulkarni AB, and Shankland SJ: Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. Am J Pathol 165: 1175-1185, 2004.
- Takahashi S, Ohshima T, Cho A, Sreenath T, Iadarola MJ, Pant HC, Kim Y,Nairn AC, Brady RO, Greengard P, Kulkarni AB: Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling, Proc Natl Acad Sci USA 102: 1737-1742, 2005
- Kohyama J, Hasegawa T. Ohinata JS, Furushima W, Miyata R, Sugawara H, Araki S: Obstructive sleep apnea and insulin resistance in Japanese children, Sleep and Biological Rhythms 3: 106-113, 2005
- Takahashi S, Ohshima T, Cho A, Sreenath T, Iadarola MJ, Pant HC, Kim Y, Nairn AC, Brady RO, Greengard P and Kulkarni AB: Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc. Natl. Acad. Sci. USA 102: 1737-1742, 2005.
- Tanaka H, Amamiya S, Miura N, Araki A, Ohinata J, Fujieda K: Postnatal development of brainstem serotonin-containing neurons projecting to lumbar spinal cord in rats. Brain Dev 28: 586-591, 2006.
- Okamoto T, Shirai M, Kokubo M, Takahashi S, Kajino M, Takase M, Sakata H, Oki J: Human milk reduces the risk of retinal detachment in extremely low birth weight infants, Pediatr Int 49: 894-897, 2007
- Okamoto T, Takahashi S, Nakamura E, Nagaya K, Hayashi T, Shirai M, Fujieda K: Matrix metalloproteinases in infants with posthemorrhagic hydrocephalus, Early Hum Dev.
- Ohinata J, Suzuki N, Araki A, Takahashi S, Fujieda K, Tanaka H: Actigraphic assessment of sleep disorders in children with chronic fatigue syndrome, Brain Dev
- Ito S, Oguni H, Ito Y, Ishigaki K, Ohinata J, Osawa M: Modified Atkins diet therapy for a case with glucose transporter type 1 deficiency syndrome, Brain Dev.
- Takahashi S, Ohinata J, Makita Y, Suzuki N, Araki A, Sasaki A, Murono K, Tanaka H, Fujieda K: Skewed X chromosome inactivation failed to explain the normal phenotype of a carrier female with MECP2 mutation resulting in Rett syndrome, Clin Genet 2007.
- Takahashi S, Ohinata J, Suzuki N, Amamiya S, Kajihama A, Sugai R, Araki A, Fujieda K and Tanaka H: Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: A successful use of zonisamide for controlling the seizures. Epilepsy Res 2008, in press
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