診療研究グループ紹介

神経グループ

神経グループは高橋 悟(講師)、鈴木菜生(医員)、岡山亜貴恵(子どもの発達診療センター助教)、岡野聡美(医員)、田中亮介(医員)の5名で構成されております。診療面ではてんかん、脳性麻痺、変性疾患、筋疾患などの診療に加え、平成19年6月より新設された「子どもの発達診療センター」では、岡山助教が中心となって自閉症、ADHD、学習障害などの発達障害の診療にあたっております。また、当グループは地域と連携した診療を重視し、関連病院や児童相談所などの神経専門外来や相談業務も担当しております。研究面では、高橋講師が中心となり発達期脳に及ぼすてんかん発作の影響を解明するため分子生物学的手法を用いながら活発に研究を行っています。また、誘発電位など客観的指標を用いた発達障害児の高次機能および治療評価、発達障害児の生体リズム解析などを中心とした臨床研究にも精力的に取り組んでおります。

スタッフ

氏名 役職 専門医/資格
高橋  悟 講師 日本小児科学会専門医/指導医
小児神経専門医
鈴木 菜生 医員 日本小児科学会専門医/指導医
小児神経専門医
岡山 亜貴恵 助教 日本小児科学会専門医/指導医
岡野 聡美 医員 日本小児科学会専門医
日本人類遺伝学会・日本遺伝カウンセリング学会臨床遺伝専門医
田中 亮介 医員 日本小児科学会専門医

研究テーマ

脳形成異常の病態解明-前脳特異的Cdk5欠損マウスをモデルとして
Glut-1欠損症の診断と病態解明
てんかん・神経発達障害の分子遺伝学的研究
脳浮腫の分子機構の解明
発達障害の分子遺伝学的研究
光トポグラフィーと持続注意課題を用いた注意および反応行動抑制障害の評価
発達障害児の睡眠障害に対するアクチグラフを用いた評価と治療の検討

取得した専門医研修施設

日本小児神経学会小児神経科専門医研修認定施設

業績

  • Inoue K, Tanaka H, Scaglia F, Araki A, Shaffer LG, Lupski JR: Compensating for central nervous system dysmyelination: femals with a proteolipid protein gene duplication and sustained clinical improvement, Ann Neurol, 50: 747-754, 2001
  • Amiel J, Espinosa-Parrilla Y, Stefann J, Gosset P, Pelet A, Prieur M, Boute O, Choiset A, Lacombe D, Philip N, Le Merrer M, Tanaka H, Till M, Touraine R, Toutain A, Vekemans M, Munnich A, Lyonnet S. Large-scale deletions and SMADIP1 truncating mutations in syndromic hirschsprung disease with involvement of midline structures, Am J Hum Genet, 69: 1370-1377, 2001
  • Takemitsu M, Mishima R, Torii T, Oka R, Tanaka H, Araki A, Cho K: The usefulness of a new electric power assist unit for wheelchairs for patients with Duchenne muscular dystrophy, The First ISPRM Congress, Amsterdam (The Netherlands); (July7-13): 543-546, 2001
  • Takahashi S, Ohsugi K, Yamamoto T, Shiomi M, Sakuragawa N: A novel approach to ex vivo gene therapy for familial hypercholesterolemia using human amniotic epithelial cells as a transgene carrier. Tohoku J Exp Med 193: 279-292, 2001
  • Kosuga M, Takahashi S, Tanabe A, Fujino M, Li XK, Suzuki S, Yamada M, Kakishita K, Ono F, Sakuragawa N, Okuyama T: Widespread distribution of adenovirus-transduced monkey amniotic epithelial cells after local intracerebral injection: implication for cell-mediated therapy for lysosome storage disorders. Cell Transplant 10: 435-439, 2001
  • Ko J, Humbert S, Bronson RT, Takahashi S, Kulkarni AB, Li E, Tsai LH: p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. J Neurosci 21: 6758-6771, 2001
  • Li BS, Sun MK, Zhang L, Takahashi S, Ma W, Vinade L, Kulkarni AB, Brady RO, Pant HC: Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc Natl Acad Sci USA 98: 12742-12747, 2001
  • Li BS, Zhang L, Takahashi S, Ma W, Jaffe H, Kulkarni AB, Pant HC: Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J 21: 324-333, 2002
  • Ohshima T, Ogawa M, Takeuchi K, Takahashi S, Kulkarni AB, Mikoshiba K: Cyclin-dependent kinase 5/p35 contributes synergistically with Reelin/Dab1 to the positioning of facial branchiomotor and inferior olive neurons in the developing mouse hindbrain. J Neurosci 22: 4036-4044, 2002
  • Takahashi S, Saito T, Hisanaga S, Pant HC, Kulkarni AB: Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J Biol Chem 278: 10506-10515, 2003
  • Li BS, Ma W, Jaffe H, Zheng Y, Takahashi S, Zhang L, Kulkarni AB, Pant HC: Cdk5 is involved in neuregulin-dependent activation of PI-3 kinase and Akt activity mediating neuronal survival. J Biol Chem,278: 35702-35709, 2003
  • Tanaka H, Habaguchi T, Nagaoka Y, Oki J, Takakusaki K: Effect of melatonin and diazepam on eye movement and postural muscle tone in decerebrate cats, Sleep and Biological Rhythms, 1: 203-208, 2003
  • Koyano S, Araki A, Hirano Y, Fujieda K, Suzutani T, Tagyu K, Murono K, Inoue N:Retrospective diagnosis of congenital cytomegalovirus infection using dried umbilical cords.Pediatr Infect Dis J.23:481-2、2004
  • Hirasawa M, Ohshima T, Takahashi S, Veeranna, Pant HC, Mikoshiba K, Brady RO and Kulkarni AB: Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects. Proc. Natl. Acad. Sci. USA 101:6249-6254, 2004.
  • Kesavapany S, Amin N, Zheng YL, Nijhara R, Jaffe H, Sihag R, Gutkind JS, Takahashi S, Kulkarni AB, Grant P and Pant HC: p35/cyclin-dependent kinase 5 phosphorylation of Ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons.  J Neurosci 24: 4421-4431, 2004.
  • Griffin SV, Hiromura K, Pippin J, Petermann AT, Blonski MJ, Krofft R, Takahashi S, Kulkarni AB, and Shankland SJ: Cyclin-dependent kinase 5 is a regulator of podocyte differentiation, proliferation, and morphology. Am J Pathol 165: 1175-1185, 2004.
  • Kohyama J, Hasegawa T. Ohinata JS, Furushima W, Miyata R, Sugawara H, Araki S: Obstructive sleep apnea and insulin resistance in Japanese children, Sleep and Biological Rhythms 3: 106-113, 2005
  • Takahashi S, Ohshima T, Cho A, Sreenath T, Iadarola MJ, Pant HC, Kim Y, Nairn AC, Brady RO, Greengard P and Kulkarni AB: Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling. Proc. Natl. Acad. Sci. USA 102: 1737-1742, 2005.
  • Tanaka H, Amamiya S, Miura N, Araki A, Ohinata J, Fujieda K: Postnatal development of brainstem serotonin-containing neurons projecting to lumbar spinal cord in rats. Brain Dev 28: 586-591, 2006.
  • Okamoto T, Shirai M, Kokubo M, Takahashi S, Kajino M, Takase M, Sakata H, Oki J: Human milk reduces the risk of retinal detachment in extremely low birth weight infants, Pediatr Int 49: 894-897, 2007
  • Okamoto T, Takahashi S, Nakamura E, Nagaya K, Hayashi T, Shirai M, Fujieda K: Matrix metalloproteinases in infants with posthemorrhagic hydrocephalus, Early Hum Dev.
  • Ohinata J, Suzuki N, Araki A, Takahashi S, Fujieda K, Tanaka H: Actigraphic assessment of sleep disorders in children with chronic fatigue syndrome, Brain Dev
  • Ito S, Oguni H, Ito Y, Ishigaki K, Ohinata J, Osawa M: Modified Atkins diet therapy for a case with glucose transporter type 1 deficiency syndrome, Brain Dev.
  • Takahashi S, Ohinata J, Makita Y, Suzuki N, Araki A, Sasaki A, Murono K, Tanaka H, Fujieda K: Skewed X chromosome inactivation failed to explain the normal phenotype of a carrier female with MECP2 mutation resulting in Rett syndrome, Clin Genet 2007.
  • Takahashi S, Ohinata J, Suzuki N, Amamiya S, Kajihama A, Sugai R, Araki A, Fujieda K and Tanaka H: Molecular analysis and anticonvulsant therapy in two patients with glucose transporter 1 deficiency syndrome: A successful use of zonisamide for controlling the seizures. Epilepsy Res 2008, in press
  • Takahashi S, Ohshima T, Hirasawa M, Pareek TK, Bugge TH, Morozov A, Fujieda K, Brady RO, Kulkarni AB: Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration. Am J Pathol 176: 320-329, 2009
  • Matsumoto N, Takahashi S, Toriumi N, Sarashina T, Makita Y, Tachibana Y, Fujieda K: Acute disseminated encephalomyelitis in an infant with incontinentia pigmenti. Brain Dev 31: 625-628, 2009
  • Okamoto T, Takahashi S, Nakamura E, Nagaya K, Hayashi T, Fujieda K: Transforming growth factor-b1 induces matrix metalloproteinase-9 expression in human meningeal cells via the ERK and Smad pathways. Biochem Biophys Res Comm 383: 475-479, 2009
  • Maimaiti M, Takahashi S, Okajima K, Suzuki N, Ohinata J, Araki A, Tanaka H, Mukai T, Fujieda K: Silent exonic mutation in the acid-alpha-glycosidase gene that causes glycogen storage disease type II by affecting mRNA splicing. J Hum Genet 54: 493-496, 2009
  • Tanaka H, Amamiya S, Takahashi S, Suzuki N, Araki A, Ohinata J, Fujieda K: Effect of neonatal hypoxia on the development of intraspinal serotonergic fibers in relation to spinal motoneurons. Brain Dev 32: 268-274, 2009
  • Muto A, Oguni H, Takahashi Y, Shirasaka Y, Sawaishi Y, Yano T, Hoshida T, Osaka H, Nakasu S, Akasaka N, Sugai K, Miyamoto A, Takahashi S, Suzuki M, Ohmori I, Nabatame S, Osawa M: Nationwide survey (incidence, clinical course, prognosis) of Rasmussen’s encephalitis. Brain Dev 32:445-53, 2010
  • Okamoto T, Takahashi S, Nakamura E, Nagaya K, Hayashi T, Shirai M, Fujieda K: Increased expression of matrix metalloproteinase-9 and hepatocyte growth factor in the cerebrospinal fluid of infants with posthemorrhagic hydrocephalus. Early Hum Dev 2010 (in press)
  • Zheng YL, Li BS, Rudrabhatla P, Shukla V, Amin ND, Maric D, Kesavapany S, Kanungo J, Pareek TK, Takahashi S, Grant P, Kulkarni AB, Pant HC: Phosphorylation of p27Kip1 at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation. Mol Biol Cell 21: 3601-3614, 2010
  • Xe H, Takahashi S, Suzuki H, Hashikawa T, Kulkarni AB, Mikoshiba K, Ohshima T: Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice. Neurochem Res 2011 (in press)
 

旭川医科大学小児科学教室

〒078-8510 北海道旭川市緑が丘東2条1丁目1の1
TEL:0166-68-2481/2483(DI) FAX:0166-68-2489

Department of Pediatrics, Asahikawa Medical University

Midorigaoka-higashi 2-1-1-1, Asahikawa, Hokkaido 078-8510, Japan
TEL:+81-166-68-2481/2483 FAX:+81-166-68-2489

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